Depression and Anxiety
March 10, 2014
Ronald S. Duman
213 citations
Stress and depression are associated with atrophy and loss of neurons in limbic and cortical brain regions that could contribute to the symptoms of depression. Typical monoamine reuptake inhibitor antidepressants have only modest efficacy and require long-term treatment, and are only weakly effective in blocking or reversing these structural changes caused by stress. Recent findings demonstrate...
Activitas Nervosa Superior
March 1, 2014
Steven Best
5 citations
Abstract By combining transcranial magnetic stimulation (TMS) with intravenous ketamine therapy, we sought to increase the therapeutic value of TMS and, at the same time, to improve the efficacy of intravenous ketamine therapy among depressed patients previously classified as non-responders. In this preliminary report, we provide evidence for a new and much more reliable method of treating...
Psychiatria Polska
February 20, 2014
Paweł Gosek, Magdalena Chojnacka, Łukasz Święcicki et al.
Cel: W ostatnich latach opublikowano wiele opisów dotyczących możliwości uzyskania szybkiej i istotnej klinicznie poprawy stanu psychicznego u pacjentów z rozpoznaniem depresji po podaniu antagonisty receptorów N-metylo-D-asparaginowych (NMDA) - ketaminy. Większość badań dotyczy podania ketaminy pacjentom z depresją lekooporną, co jednak nie oznaczało oporności na leczenie elektrowstrząsowe. W...
Journal of Affective Disorders
February 18, 2014
D. Luckenbaugh, Mark J. Niciu, Dawn F. Ionescu et al.
282 citations
Background The N-methyl-D-aspartate receptor antagonist ketamine has rapid antidepressant effects in major depression. Psychotomimetic symptoms, dissociation and hemodynamic changes are known side effects of ketamine, but it is unclear if these side effects relate to its antidepressant efficacy. Methods Data from 108 treatment-resistant inpatients meeting criteria for major depressive disorder...
Medicine Today
February 10, 2014
Mohammad Shafiqur Rahman Patwary, Kazi Abdullah Al Mamun
4 citations
Drug abuse has reached epidemic proportions in many countries including Bangladesh and threatens to overwhelm economic, social, and health care systems. In addition to their effects on the central nervous system, many of these agents induce profound changes in the heart and circulation that are responsible for a significant proportion of drug-related morbidity. Drugs that can affect the...
Research in Neurology An International Journal
February 3, 2014
Botros B. Shenoda
4 citations
The noncompetitive NMDA receptor blocker ketamine provides significant improvement to patients suffering from depression but its mechanistic pathways are not fully understood.The endogenous opioid system is known to be dysregulated in patients with depression.Ketamine is known to interact with the opioid system either directly or indirectly through the release of endogenous opioids.In this...
Drug and Alcohol Dependence
January 15, 2014
Elias Dakwar, C. Anerella, Carl L. Hart et al.
125 citations
Background Sub-anesthetic ketamine infusions may benefit a variety of psychiatric disorders, including addiction. Though ketamine engenders transient alterations in consciousness, it is not known whether these alterations influence efficacy. This analysis evaluates the mystical-type effects of ketamine, which may have therapeutic potential according to prior research, and assesses whether these...
The Annual Review of Pharmacology and Toxicology
January 6, 2014
Mark J. Niciu, Ioline D. Henter, David A. Luckenbaugh et al.
166 citations
The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid and potent antidepressant effects in treatment-resistant major depressive disorder and bipolar depression. These effects are in direct contrast to the more modest effects seen after weeks of treatment with classic monoaminergic antidepressants. Numerous open-label and case studies similarly validate ketamine's antidepressant...
The International Journal of Psychiatry in Medicine
2014
M L Zuccoli, A Muscella, C Fucile et al.
Ketamine is an anaesthetic and analgesic drug synthesized in the 1960s from phencyclidine. The recreational use of ketamine increased among the dance culture of techno and house music, in particular in clubs, discotheques, and rave parties. The psychotropic effects of ketamine are now well known and they range from dissociation to positive, negative, and cognitive schizophrenia-like symptoms....
Drug Testing and Analysis
2014
Hamilton Morris, Jason Wallach
240 citations
PCP or phencyclidine was discovered in 1956 and soon became a popular street drug. Dissociatives including PCP, ketamine, and dextromethorphan have been used non-medically for their mind-altering effects for over 60 years. Many of these compounds have also been used clinically and in legitimate research. At least 14 derivatives of PCP were sold for non-medical and illict use from the late 1960s...