The Journal of Clinical Psychiatry
April 24, 2024
Gregory H Jones, Courtney M Vecera, Ana C Ruiz et al.
13 citations
Objective: Although individuals with a family history of alcohol use disorder (AUD) have a superior antidepressant response to ketamine, outcomes in patients with current AUD remain unclear. This study sought to investigate whether intranasal (IN) racemic (R,S)-ketamine had antisuicidal and antidepressant effects in unipolar and bipolar depression and whether comorbid AUD conferred superior...
Journal of Medical Case Reports
March 3, 2024
Alireza Teymouri, Hadis Nasoori, Maryamsadat Fakheri et al.
20 citations
Anesthesiologists prefer ketamine for certain surgeries due to its effectiveness as a non-competitive inhibitor of the N-methyl-D-aspartate receptor in the brain. Recently, this agent has also shown promise as an antidepressant. However, ketamine can cause hallucinogenic effects and is sometimes abused as an illicit drug. Ketamine abuse has been associated with liver and bile duct...
Alpha psychiatry
March 1, 2024
Anna Famuła, Jakub Radoszewski, Tomasz Czerwiec et al.
8 citations
Substance use disorder (SUD) continues to pose a significant global health challenge, necessitating innovative and effective therapeutic interventions. Ketamine, traditionally recognized for its anesthetic properties, has emerged as a novel and promising avenue for the treatment of SUD. This narrative review critically examines the current body of literature surrounding the use of ketamine in...
Nature Communications
January 30, 2024
Tommaso Di Ianni, Sedona N. Ewbank, Marjorie R. Levinstein et al.
Subanesthetic ketamine is increasingly used for the treatment of varied psychiatric conditions, both on- and off-label. While it is commonly classified as an N -methyl D-aspartate receptor (NMDAR) antagonist, our picture of ketamine’s mechanistic underpinnings is incomplete. Recent clinical evidence has indicated, controversially, that a component of the efficacy of subanesthetic ketamine may...
Frontiers in Pharmacology
2024
Carles Colom-Rocha, Cristian Bis-Humbert, M Julia García-Fuster
3 citations
Few studies have previously evaluated the long-term impact of initiating the combined use of alcohol and cocaine early-in-life during adolescence. Our preclinical study characterized changes in affective-like behavior and/or voluntary ethanol consumption emerging later on in adulthood induced by a prior adolescent drug exposure, as well as tested therapeutical interventions (i.e., cannabidiol...
Frontiers in Pharmacology
2024
Luan Oliveira Ferreira, Esther Padilha da Silveira, Clarissa A Paz et al.
Substance abuse is a major public health problem. In recent years, ketamine, which is a parenteral anesthetic, has been consumed increasingly as an illicit drug together with alcohol, although little is known of how this association alters brain activity. The present study investigated the influence of progressive doses of ketamine, associated with alcohol, on electrophysiological activity. For...
Pharmaceuticals
December 21, 2023
Katarina Savić Vujović, Ana Jotić, Branislava Medić et al.
32 citations
Ketamine as an old-new drug has a variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine in standard doses is principally utilized for the induction and maintenance of surgical procedures. Besides its use in anesthesia and analgesia, recent studies have shown that ketamine has found a place in the treatment of asthma, epilepsy,...
Drug and Alcohol Dependence
December 1, 2023
Caryssa R Drinkuth, Michael J Lehane, Gregory C Sartor
9 citations
Despite the thousands of lives lost during the ongoing opioid crisis, a scarcity of new and effective clinical treatments for opioid use disorder (OUD) remains. To address this unmet need, some researchers have turned to dissociative and psychedelic drugs to treat multiple psychiatric conditions. In particular, low doses of ketamine have been shown to attenuate opioid withdrawal and drug use in...
Journal of Health, Medicine and Nursing
November 1, 2023
Prince Opuni Frimpong
1 citation
Ketamine, a dissociative anesthetic commonly used in medical settings, has shown promising results in treating various mental health disorders. Recent studies have suggested its potential repurposing for treating cocaine use disorder (CUD). However, before implementing such a treatment approach, it is crucial to consider the ethical and legal constraints associated with it from a Ghanaian...
Pharmacology, biochemistry, and behavior
June 1, 2023
M L Shawn Bates, Keith A Trujillo
Initiation of non-medical dextromethorphan (DXM) use often occurs in adolescence, yet little is known about the consequences when use begins during this developmental period. The current experiments examined the acute response and the effects of repeated exposure to DXM in adolescence on behavior in adulthood. We examined locomotor activity, locomotor sensitization, and cognitive function, in...