Ibogaine is a psychedelic alkaloid that has attracted large scientific interest because of its antiaddictive properties in observational studies in humans as well as in animal models. Its subjective effect has been described as intense, vivid dream-like experiences occurring while awake; hence, ibogaine is often referred to as an oneirogenic psychedelic. While this unique dream-like profile has...
Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known for over 120 years, these small molecules continue to challenge our...
Ibogaine is a psychotropic indole alkaloid extracted from the roots of the Tabernanthe iboga shrub from the Apocynaceae family. Depending on the taken dose, it can lead to stimulant effects, euphoria, visual and auditory hallucinations, along with auditory, olfactory, and gustatory synesthesia. In addition to its historical usage in spiritual rituals of African tribes, these days iboga extract...
HIGHLIGHTS The ibogain action has not been completely clarified. Honey bee midgut is suitable model system for testing the antioxidative mechanisms. The ex vivo ibogaine treatment induced an up-regulation of Sod1 gene. Ibogaine shows pro-antioxidant action.
The development of non-animal-based new approach methodologies (NAMs) for chemical risk assessment and safety evaluation is urgently needed. The aim of the present study was to investigate the applicability of an in vitro-in silico approach to predict human cardiotoxicity of the herbal alkaloid ibogaine and its metabolite noribogaine, which are promising anti-addiction drugs. Physiologically...
Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders. In animal models, ibogaine reduces ethanol self-administration. However, no study to date has investigated the effects of ibogaine on ethanol-induced conditioned place preference (CPP). The present study aimed...
Abstract Ibogaine is a psychoactive alkaloid contained in the West African plant Tabernanthe iboga. Although preliminary, evidence suggests that ibogaine could be effective in the treatment of certain substance use disorders, specifically opioid use disorder. This narrative review concentrated on the pharmacological, cultural and psychological aspects of ibogaine that contribute to its reputed...
By systematically tweaking the structure of the psychedelic compound ibogaine, chemists have created a molecule that may someday find use as a treatment for neuropsychiatric disorders, including depression and addiction. The compound, which the researchers call tabernanthalog, has a simpler structure than ibogaine, making it easier to synthesize. Researchers in David E. Olson’s lab at the...
In July 2018 we met at the airport, my brother and I. We were bound for Portugal, where my brother was about to undergo treatment for his heroin addiction. A visual essay following an Ibogaine treatment. By artist and curator, Sagit Mezamer The imagery in this essay is taken from drawings and photographs from Mezamer's new artwork - The Mother of Opium.