The effects of ibogaine on antioxidant mechanisms remain incompletely understood. Using honey bee midgut as an ex vivo model system, ibogaine treatment induced up-regulation of the Sod1 gene, indicating a pro-antioxidant action.
Mimosa tenuiflora (jurema-preta), a hallucinogenic plant used traditionally by indigenous peoples in northeastern Brazil for curing and divination, is reviewed for its uses, phytochemistry, and pharmacology. The plant induces altered states of consciousness and has therapeutic applications. This review covers the plant's traditional use, chemical constituents, and pharmacological effects, providing a comprehensive overview of its ethnopharmacological significance.