A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans.
ALTEX January 1, 2021 Miaoying Shi, Sebastiaan Wesseling, Hans Bouwmeester et al. 13 citations
A non-animal approach combining lab-grown human heart cells with computer modeling accurately predicted the heart side effects of two anti-addiction drugs, ibogaine and its metabolite noribogaine. The method used human stem cell-derived heart cells on a multi-electrode array to measure concentration-dependent prolongation of field potential duration, a sign of cardiotoxicity. Physiologically based kinetic models then translated these lab results into predicted dose-dependent QTc prolongation in humans. The predictions matched published human data, demonstrating that this new approach methodology can replace animal testing for cardiac safety evaluation.