A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans.
ALTEX 2021 Miaoying Shi, Sebastiaan Wesseling, Hans Bouwmeester et al. 13 citations
The development of non-animal-based new approach methodologies (NAMs) for chemical risk assessment and safety evaluation is urgently needed. The aim of the present study was to investigate the applicability of an in vitro-in silico approach to predict human cardiotoxicity of the herbal alkaloid ibogaine and its metabolite noribogaine, which are promising anti-addiction drugs. Physiologically...
DOI: 10.14573/altex.2103311 (opens in new tab)
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Cardiac safety evaluation
Reverse dosimetry
Non-animal approach
Assessing drug safety
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