Scientific Reports
March 10, 2022
Anna Ciaunica, Luke McEllin, Julian Kiverstein et al.
Depersonalisation is a common dissociative experience characterised by distressing feelings of being detached or 'estranged' from one's self and body and/or the world. The COVID-19 pandemic forcing millions of people to socially distance themselves from others and to change their lifestyle habits. We have conducted an online study of 622 participants worldwide to investigate the relationship...
medRxiv
March 2, 2022
Maggie Kiraga, Kim P. C. Kuypers, Malin V. Uthaug et al.
preprint
Abstract Anxiety disorders are the most common type of psychiatric disorders among Western countries. Evidence-based treatment modalities including pharmacological and cognitive-behavioral therapy result in relatively low response rates (average range: 51 - 58%). Historical and recent research suggests psychedelic drugs may be efficacious in alleviating anxiety-related symptoms among healthy...
Journal of Psychopharmacology
March 1, 2022
Catherine Bird, A. H. Young
As we head into the (Northern Hemisphere) spring, the Journal publishes another set of papers which illustrate the robust health of the science of psychopharmacology. Once again, papers mostly focus on psychedelic drugs and related topics reflecting the zeitgeist (Young, 2022). de Wit et al. (2022) explore translational challenges and opportunities between clinical research and laboratory...
Journal of Psychopharmacology
March 1, 2022
Malin Vedøy Uthaug, Alan K. Davis, Trevor Forrest Haas et al.
64 citations
Mescaline is a naturally occurring psychoactive phenethylamine found in several cacti and historically used ceremonially by Indigenous and Latin American populations. Broader recognition of its possible therapeutic value in Western science began in the 1950s; however, knowledge of the safety profile of mescaline and the extent of its use remains limited. The primary aim of this study is to...
Neuropsychopharmacology
February 25, 2022
Friederike Holze, Laura Ley, Felix Müller et al.
223 citations
Abstract Growing interest has been seen in using lysergic acid diethylamide (LSD) and psilocybin in psychiatric research and therapy. However, no modern studies have evaluated differences in subjective and autonomic effects of LSD and psilocybin or their similarities and dose equivalence. We used a double-blind, randomized, placebo-controlled, crossover design in 28 healthy subjects (14 women,...
Journal of Neurochemistry
February 12, 2022
Johannes T. Reckweg, Malin V. Uthaug, Attila Szabo et al.
108 citations
Abstract 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) is a naturally occurring tryptamine that primarily acts as an agonist at the 5‐HT1A and 5‐HT2A receptors, whereby affinity for the 5‐HT1A subtype is highest. Subjective effects following 5‐MeO‐DMT administration include distortions in auditory and time perception, amplification of emotional states, and feelings of ego dissolution that...
Psychopharmacology
January 24, 2022
Kim van Oorsouw, S. W. Toennes, J. G. Ramaekers
71 citations
RATIONALE: Studies have suggested mental health improvements following the use of the psychotropic plant concoction ayahuasca in non-clinical and clinical samples. OBJECTIVES: The present observational study assessed depressive symptomatology in 20 clinically depressed patients (symptom score > 13 on the Beck's Depression Inventory) before attendance of an ayahuasca ceremony and 1 month and 1...
Metodo
2022
Jérôme Dokic
A BSTRACT . In both literature and science, descriptions abound of so-called “self-transcendent” experiences, which seem to deeply alter the boundaries between oneself and the rest of the world. The subjects of these experiences often report that they feel extended to the world, united with it, or on the contrary retracted from it, as if they were tiny or insignifcant. Sometimes, they report...
Journal of Daoist Studies
2022
Lonny S. Jarrett
Deepening Perspectives on Spirit Lonny S. Jarrett1 (bio) A human being is a part of the whole, called by us “Universe,” a part limited in time and space. He experiences himself, his thoughts and feelings as something separated from the rest, a kind of optical delusion of his consciousness. This delusion is a kind of prison for us, restricting us to our personal desires and to affection for a...
eScholarship@McGill
2022
Khaleel Rajwani
Despite the culturally diverse history of psychedelics, dominant cultural assumptions constrain emerging psychedelic healing practices and therapeutic models in contemporary Western biomedical practice. I draw on Kirmayer’s “Psychotherapy and the Cultural Concept of the Person” (2007) to discuss how the emerging model of psychedelic psychotherapy inherits the egocentric cultural concept of self...