Psychiatry Research
October 1, 2026
Jaime Rojas-Hernández, Lucas F Borkel, Ángelo Santana Del Pino et al.
This study examines acute and delayed adverse reactions reported in naturalistic psychedelic use, focusing on their associations with substance-use patterns, contextual variables, and user motivations. Using an online survey incorporating the Psychedelic Use Scale, data were collected from a large naturalistic sample (N=1022) to analyze patterns of self-reported adverse reactions. Acute adverse...
Aracê.
September 29, 2026
Renato Lemes Peixoto, Lígia Freitas
A Ayahuasca é uma preparação de origem amazônica tradicionalmente produzida a partir da combinação de Banisteriopsis caapi e Psychotria viridis, contendo compostos biologicamente ativos como N,N-dimetiltriptamina (DMT), harmina, harmalina e tetrahidroharmina. Nas últimas décadas, sua utilização ultrapassou os contextos tradicionais e religiosos amazônicos, alcançando centros urbanos e...
Industrial Psychiatry Journal
September 25, 2026
Julio Torales, Marcelo O’Higgins, Iván Barrios et al.
ABSTRACT: Ayahuasca, a traditional Amazonian brew containing N,N-dimethyltryptamine (DMT) and β-carboline monoamine oxidase inhibitors, has expanded globally beyond Indigenous ceremonial systems. While acute visionary and psychotomimetic effects are expected and culturally integrated in ritual contexts, concerns have emerged about persistent psychotic symptoms in vulnerable individuals. This...
European Neuropsychopharmacology
September 19, 2026
Maia Mallevays, Lucie Berkovitch
Classic psychedelics, including lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT), have re-emerged as promising treatments for psychiatric conditions linked to suicidality. However, rare reports of increased suicidality potentially associated with psychedelic use have raised safety concerns. This article examines the complex relationship between psychedelics and...
Revista JRG de Estudos Acadêmicos
September 16, 2026
Monique Vieira de Moura, Heder Albuquerque Azevedo Rocha, Márcio José de Carvalho Lima et al.
A depressão resistente ao tratamento (DRT) representa uma condição de elevada carga clínica e funcional, usualmente definida pela resposta inadequada a pelo menos dois tratamentos antidepressivos adequados. O interesse por psicodélicos clássicos ressurgiu diante da possibilidade de efeitos antidepressivos rápidos após uma ou poucas administrações em contexto supervisionado. O objetivo desta...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Flávio Marco Rego da Silva
preprint
The ratio R = E/|O_info| - spectral energy per unit of integrated informational structure - was proposed as a candidate outcome observable of the thermodynamics of consciousness: an energetic cost per nat of integration. We report its complete empirical genealogy across eight pre-registered studies in public datasets (Sleep-EDF, 153 nights, N=76/77; DOSE-I propofol, N=170; 62-channel ketamine,...
medRxiv
September 10, 2026
Mori Krantz, Mark C. Haigney, Mary Ross Southworth et al.
preprint
Background: Several Schedule I substances have demonstrated potential benefits for refractory psychiatric conditions and addiction. Some have been legalized at the state level, while others like kratom (mitragynine) are available over-the-counter in some states and illegal in others. A recent presidential executive order directs certain federal agencies to accelerate development and facilitate...
The International Journal of Neuropsychopharmacology
September 9, 2026
Claudio Agnorelli, Joseph Peill, Danielle Kurtin et al.
Abstract Background Clinical studies have shown that ketamine and classic psychedelics can produce robust and rapid antidepressant effects after a single or a few administrations. However, the neurobiological mechanisms driving these long-lasting changes remain unclear. A leading framework proposes that both drug classes induce sustained increases in neuroplasticity, potentially reshaping...
The International Journal of Neuropsychopharmacology
September 9, 2026
B Richardson, J O'Byrne, V Bruno et al.
Abstract Background Psychedelics induce altered states of consciousness (AOC) with profound perceptual, cognitive, and emotional shifts, often linked to positive therapeutic outcomes. Although serotonergic psychedelics such as psilocybin, LSD, and 5-MeO-DMT share receptor targets, they differ in behavioral and neural effects. How these compounds alter cortical dynamics relative to other...
The International Journal of Neuropsychopharmacology
September 9, 2026
J Vieira-Andrade, I Marques, M Brito
Abstract Background Serotonin 2A receptor (5-HT2AR) agonists play a crucial role in multiple cognitive processes, namely executive functions, learning and memory. Owing partly to this, psychedelics such as lysergic acid diethylamide (LSD), psilocybin, dimethyltryptamine (DMT), mescaline and ayahuasca might be valuable adjuvants in improving memory deficits and language impairment. Thanks to...