Neuropharmacology
December 1, 1985
G Seeman, G M Brown
5 citations
The present study was performed to examine the central effects of the indolealkylamine hallucinogens, 5-methoxy-N,N-dimethyltryptamine (MDMT), bufotenin and N, N-dimethyltryptamine (DMT), infused intracerebroventricularly (i.c.v.) into the lateral ventricle. They were found to have a stimulatory effect upon the secretion of prolactin. Their order of potency was compared. From a...
Journal of Neurochemistry
September 1, 1985
U Spampinato, E Esposito, R Samanin
36 citations
The effects of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) and m-chlorophenylpiperazine (CPP), two 5-hydroxytryptamine (5-HT, serotonin) agonists, on the accumulation of 3,4-dihydroxyphenylalanine (DOPA] were studied in the striatum of rats treated with gamma-butyrolactone (GBL). Unlike 2 mg/kg i.p. apomorphine, neither 5 mg/kg i.p. 5-MeO-DMT nor 2.5 mg/kg i.p. CPP significantly reduced the...
Journal of Pharmacology and Experimental Therapeutics
July 1, 1985
E. B. Nielsen
Four monkeys (Cercopithecus aethiops) were trained to discriminate 0.06 mg/kg of lysergic acid diethylamide (LSD) from saline in a two-key task in which correct responding was reinforced with food under a fixed ratio 32 schedule. The ED50 of LSD was 0.011 mg/kg. The nonhallucinogenic ergot, lisuride, and the hallucinogen, 5-methoxy-N,N-dimethyltryptamine, substituted completely for LSD (ED50...
Life Sciences
July 1, 1985
M A Sills, I Lucki, A Frazer
54 citations
Repeated administration to rats of the 5-HT1A-selective agonist 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) produced tolerance to the ability of a test dose of 5-MeODMT to produce the serotonin behavioral syndrome, but not to the ability of a test dose of the 5-HT1B-selective agonist m-chlorophenylpiperazine (mCPP) to decrease locomotor activity. Conversely, repeated administration of mCPP...
Journal of pharmacological methods
June 1, 1985
P Martin, H Frances, P Simon
21 citations
Intraperitoneal injection of 5-hydroxytryptophan and 5-methoxy-N,N-dimethyltryptamine is shown to provoke characteristic behaviors in mice that can be quantified. The two principal phenomena described here are head twitches and tremors. Tremors became more frequent when doses of the two substances studied were increased. Head twitches appeared at lower doses, but beyond a certain dose, they...
Pharmacology, Biochemistry, and Behavior
May 1985
David J. Mokler, K W Stoudt, Richard H. Rech
Indolealkylamine and phenethylamine hallucinogens disrupted responding maintained under a fixed-ratio 40 (FR-40) schedule of reinforcement. LSD, DMT, mescaline and DOM produced dose-dependent decreases in number of reinforcers and increases in 10-sec periods of non-responding (pause-intervals). The 5HT agonist quipazine, as well as the LSD congener lisuride, altered response patterns in a...
Archives of Disease in Childhood
March 1, 1985
I A Auchterlonie, B. Benjamin
2 citations
1141 Objectives: The ayahuasca effect refers to the potentiation of action of hallucinogenic tryptamine alkaloids by co-administration of a plant extract containing MAO inhibitors, especially the beta-carboline harmine. The hallucinogenic tryptamines in the ayahuasca drink are primarily DMT and 5-MeO-DMT, the same tryptamines in extracts of Bufo skin, and the snuff yopo, another South American...
Pharmacology, Biochemistry, and Behavior
March 1, 1985
Gary A. Gudelsky, J I Koenig, Herbert Y. Meltzer
54 citations
The incidence of "wet dog" shakes elicited by quipazine, the hyperthermic response induced by 5-methoxy-N,N-dimethyltryptamine (5MeODMT) and the hypothermic response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) were compared in rats of the Fawn-Hooded (FH) and Sprague-Dawley (SD) strains. The behavioral responses of FH rats to quipazine and 5MeODMT were significantly greater than...
Psychopharmacology
1985
E B Nielsen, J B Appel
Rats were trained to press a lever under a variable-interval (VI) schedule of water reinforcement. After stable responding had developed, a 4.5-KHz tone (CS) was conditioned classically to a 2.5-mA electric shock (US) in groups of animals which had been given various psychoactive drugs or saline. Twenty-four hours later, a stimulus generalization test was conducted in the absence of drug;...
Humana Press eBooks
1985
D. L. Murphy, L. Tamarkin, N. A. Garrick et al.
3 citations
Tryptamine has been widely accepted as a trace amine in brain, and several reviews of its metabolism, regional localization in brain, and possible neuroregulatory functions have been published (Jones, 1982; Juorio and Durden, 1984). Other endogenously synthesized indoleamines have received only minimal attention in several review monographs and symposium volumes devoted to the trace amines...