Dissociation of head twitches and tremors during the study of interactions with 5-hydroxytryptophan in mice.
Journal of pharmacological methods June 1, 1985 DOI: 10.1016/0160-5402(85)90019-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | 5-hydroxytryptophan 5-methoxy-N N-dimethyltryptamine |
| Citations | 21 |
| Key findings | Head twitches and tremors in mice are provoked by 5-hydroxytryptophan and 5-methoxy-N,N-dimethyltryptamine, with tremors increasing and head twitches decreasing at higher doses. |
Abstract
Intraperitoneal injection of 5-hydroxytryptophan and 5-methoxy-N,N-dimethyltryptamine is shown to provoke characteristic behaviors in mice that can be quantified. The two principal phenomena described here are head twitches and tremors. Tremors became more frequent when doses of the two substances studied were increased. Head twitches appeared at lower doses, but beyond a certain dose, they decreased and even disappeared. The effects on these movements of agents that modify serotonin function were then studied. The results pose problems of interpretation that are discussed.
Citations in the library
Cited by 2
Cites 2
- Behavioral effects of 5-methoxy-N:N-dimethyltryptamine, other tryptamines, and LSD American Journal of Physiology-Legacy Content July 1, 1962
- Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Journal of Pharmacy and Pharmacology September 1, 1978