Current Topics in Behavioral Neurosciences
2022
Matthew W. Johnson
31 citations
This manuscript reviews research suggesting that classic psychedelics (5-HT2A receptor agonists) are effective in treating addictions including tobacco use disorder. I review historical research from the 1950s to 1970s suggesting that classic psychedelics are associated with addiction recovery across pharmacologically distinct drugs of addiction. I then review anthropological reports about...
Current Topics in Behavioral Neurosciences
2022
Matthias E. Liechti, Friederike Holze
35 citations
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and posttraumatic stress disorder, among others....
PeerJ
2022
Alessandro M Varani, Saura R Silva, Simone Lopes et al.
7 citations
Psychotria viridis (Rubioideae: Rubiaceae), popularly known as chacrona, is commonly found as a shrub in the Amazon region and is well-known to produce psychoactive compounds, such as the N,N-dimethyltryptamine (DMT). Together with the liana Banisteropsis caapi, P. viridis is one of the main components of the Amerindian traditional, entheogenic beverage known as ayahuasca. In this work, we...
Current Topics in Medicinal Chemistry
December 2, 2021
Teresa Reynolds de Sousa, João Rema, Sérgio Machado et al.
7 citations
Background: The therapeutic options for neurobehavioral disorders are still limited, and in many cases, they lack a satisfactory balance between efficacy and side effects. Objective: This work aims to review current evidence regarding the potential contribution of psychedelics and hallucinogens to the discovery of new drugs for treating different psychiatric disorders. Discussion:...
RCMOS - Revista Científica Multidisciplinar O Saber
November 22, 2021
Robenilson Diniz Alves, Epifanio Fernandes da Silva, Maria Loyse da Silva Fernandes et al.
Depression is a chronic psychiatric illness that causes deep sadness and a strong feeling of hopelessness. In this sense, new therapies are being approached. Ayahuasca tea is an example, a drink made from the vine of the Banisteriopsis caapi.and the leaves of Psycotria viridis often used in religious rituals such as santo-daime, and which has also been shown to be effective in the treatment of...
Travel Medicine and Infectious Disease
November 1, 2021
Sherilyn K. D. Houle, Derek Evans, Caitlin Carter et al.
19 citations
BackgroundAyahuasca is a psychotropic drink made from the Amazonian vine Banisteriopsis caapi. Active components include beta-carboline alkaloids and the hallucinogen N-N-dimethyltryptamine (DMT). This review aimed to identify and summarize the literature on the safety and effectiveness of ayahuasca among recreational users.MethodA comprehensive literature search was done on November 1, 2019 in...
Frontiers in Psychology
October 28, 2021
Bernd Brabec de Mori
15 citations
During the last decades, ayahuasca gained much popularity among non-Indigenous and out-of-Amazonia based populations. In popular culture, it has been advertised as a natural remedy that was discovered by Indigenous peoples ante millennia and that has been used for shamanic healing of all kinds of ailments. This “neo-shamanic,” and often recreational, use of ayahuasca, however, has to be...
Şırnak Üniversitesi İlahiyat Fakültesi Dergisi
October 27, 2021
Nadide Şahin
2 citations
Algı ve durum değişikliğine neden olan halüsinojenik bileşikler içeren psikoaktif bitkilerin binlerce yıldır yerli halklar tarafından ritüellerde kullanıldığı bilinmektedir. Bu bağlamda psikoaktif bir içecek olan ayahuasca eski zamanlardan beri Amazon ormanlarında yaşayan çok sayıda yerli kabilenin dinî, tıbbî, sosyal ve sanatsal yaşamlarında önemli bir yere sahiptir. Ayahuascayı insanın ruhsal...
ChemRxiv
October 26, 2021
Alexzander Samuelsson, Eric Janusson, Sajni Shah et al.
2 citations
preprint
The alkaloid psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and the neurologically active psilocin (4-hydroxy-N,N-dimethyltryptamine) are the foremost compounds of pharmaceutical interest in Psilocybe mushrooms. As these compounds are infrequently analyzed in analytical labs, validated methods for rapid purity analysis are lacking. Newfound therapeutic use has invigorated academic and...
Brazilian Journal of Natural Sciences
October 12, 2021
Beatriz Souza Silva, Giovanna Pereira Lima, Isabela Rodrigues Alencar Dos Santos et al.
2 citations
Doença comum atualmente, a depressão, quando diagnosticada, é tratada com fármacos antidepressivos, sendo os inibidores seletivos da receptação de serotonina (ISRSs) considerados os de primeira escolha. Tanto esta quanto as demais classes de antidepressivos costumam apresentar efeitos adversos, que muitas vezes levam ao abandono do tratamento pelo paciente. Um outro desafio no tratamento da...