Current BiologyApril 21, 2025Jovin R Jacobs, Adam D Douglass
A hallmark of depression is a tendency to become passive when faced with overwhelming challenges. A recent study models this phenomenon in zebrafish and discovers a novel mechanism by which the antidepressant drug ketamine promotes long-term improvements in behavioral persistence.
Psilocybin is an active alkaloid found in magic mushrooms (Psilocybe cubensis). It is classified as a Class I Psychoactive Substance due to its psychoactive properties. Recent research has suggested that psilocybin holds potential for treating major depressive disorder. The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for psilocybin and its active...
Subanesthetic ketamine is currently used as a rapid-acting treatment for varied neuropsychiatric disorders. However, the mechanistic underpinnings of its therapeutic action remain unclear, and emerging clinical and preclinical evidence highlights a potential involvement of the opioid system. We used pharmacological functional ultrasound imaging data acquired during and after ketamine...
Behavioral SciencesApril 18, 2025Laura García-pérez, Rosario Padial-Ruz, Mar Cepero-González et al.2 citations
(1) Background: University students' mental health (MH) is in crisis due to academic stress, lack of physical activity (PA), and low self-esteem. This study evaluated a 12-week PA and meditation intervention to enhance psychological well-being in Spanish university students. (2) Methods: A quasi-experimental design was used, with a non-randomized control group and pretest-posttest assessments....
JURNAL EDUSCIENCEApril 17, 2025Muhamad Rozikan, A. Adisti, Muhammad Istiqlal
Purpose – This research explores the role of mindfulness counseling in reducing episodes of mania and depression in clients diagnosed with bipolar disorder within the context of Islamic higher education institutions. The study is framed within Kabat-Zinn’s theory of Mindfulness-Based Stress Reduction (MBSR), which emphasizes present-moment awareness and non-judgmental acceptance alongside the...
AbstractBackground and aimsPsychedelic and MDMA-assisted psychotherapy are at the forefront of new treatment models for mental illnesses such as PTSD and depression, as well as improving well-being. Mindfulness meditation and loving-kindness meditation have also gained research traction, showing promise for enhancing emotional regulation and psychological well-being. This paper explores the...
JBI evidence synthesisApril 16, 2025Laura Borges Lopes Garcia Leal, Jadson Nilo Pereira Santos, Valquíria Aparecida da Silva et al.
This scoping review will map the available evidence on nursing care provided to adults receiving ketamine infusion for pain management in hospitals and outpatient clinics. The use of intravenous ketamine infusions has increased in various contexts, particularly for pain management as part of a multimodal approach. Although ketamine is associated with a lower risk of hemodynamic disorders and...
Psilocybin, the prodrug to the psychoactive compound in 'magic' mushrooms, is currently being studied in clinical trials as a treatment for severe mental health conditions, such as depression and anxiety. Previous reports of psilocybin biosynthesis as reconstituted in E. coli reported maximum titers of 1.16 g/L, exclusively using genes from the most common recreationally used mushroom,...
Psychology, Health & MedicineApril 15, 2025Carlos Said Páez-márquez, Elkin Higuera-Dagovett, Jaime Tomás Rojas-Valencia1 citation
Traditional management strategies for diabetes primarily focus on behavioural risk factors and pharmacological therapies. Furthermore, mindfulness-based interventions (MBIs) aim to assist patients in recognising and accepting sensations, emotions and cognitions without automatic reactivity. This approach can potentially enhance glycaemic control and mental health in diabetic patients. This...
Meditation, traditionally seen as a path to spiritual enlightenment, is commonly used in therapeutic contexts for its mental health benefits, such as reducing stress, anxiety, and depression. However, alongside these benefits, practitioners of diverse forms of meditation have repeatedly been reporting adverse effects (AEs) of meditation. While most of these AEs are transient, some of them are...