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Depression: all studies

Page 585 of 1,034: studies 5,841 to 5,850 of 10,336, newest first. Back to the depression overview

Research

Disturbing dreams, nightmares, and psychological distress are predictors of poor sleep quality.

University Library Heidelberg April 1, 2025 Ian C. Dunican, Hailey Meaklim, Mitchell Turner et al.

Objective: Up to 40% of adults report poor sleep quality, yet research investigating the role of nightmares on sleep quality is limited. This study aimed to characterise the prevalence of disturbing dreams and nightmares and their relationship to poor sleep quality. Method: 439 adults (310 females, Mage=44.9 years) completed an online survey investigating sleep, dreams, nightmares, and mental...

Salivary Oxytocin as a Biomarker in Psychedelic Assisted Psychotherapy

European Psychiatry April 1, 2025 L. Cazorla, Sylvie Alaux, Cédric Mabilais et al.

Introduction One of the main mechanisms of action of LSD in psychedelic-assisted psychotherapy (PAP) is the activation of 5HT2A receptors. This triggers a cascade of neurochemical processes with the release of neurotransmitters and neurohormonal substances. The release of oxytocin in this process is well documented in pre-clinical studies, with recent evidence in healthy subjects. We have no...

Webbed Attachments: Psychedelic Lessons from the Multiverse

Theory & Event April 1, 2025 Ramzi Fawaz 1 citation

Abstract: This essay explores how the fundamental qualities of the psychedelic experience—including heightened affective intensity, the disorganization of the ego, and a sense of cosmic interconnectedness with the universe—offers a hopeful alternative to contemporary left-wing identitarianism. This is a widely popular political logic that associates the pursuit of social justice with the...

Antidepressant effect of ketamine unrelated to dissociation: Results from an exploratory mediation analysis of the KET01-02 study

European Psychiatry April 1, 2025 Lars Arvastson, Evangelos Papanastasiou, Karin Schmid et al.

IntroductionCurrent ketamine-based therapies for treatment-resistant depression (TRD) can induce dissociative symptoms. A novel oral prolonged-release ketamine formulation (KET01) results in a lower and delayed peak concentration of ketamine, and a higher concentration of the metabolites norketamine and hydroxynorketamine than after intravenous administration. KET01 has limited dissociative...

Comparing Substance Use Consequences between Serotonergic Psychedelics, MDMA, and other Drugs of Abuse Among United States Adults with History of Psychiatric Illness

International Journal of Mental Health and Addiction April 1, 2025 Joshua C. Black, Nicole Schow, Hannah L. Burkett et al. 3 citations

Psychedelic-assisted therapy could transform treating psychiatric illness, but harms from exacerbating substance use disorder (SUD) among adults with psychiatric illness using psychedelics have not been studied. A cross-sectional survey in the US was used to test whether Drug Abuse Screening Test scores (DAST-10, validated instrument predicting SUD) were more severe when psychiatric illnesses...

Tripping on Mushrooms with Edward Said: The Case for Literary Studies as Holistic Medicine

South Atlantic Quarterly April 1, 2025 Ramzi Fawaz

This piece introduces the special issue of SAQ “Psychedelic Imaginaries,” which collates fresh and theoretically sophisticated humanist perspectives on the contemporary psychedelic renaissance. Recent interdisciplinary research into psychoactive substances like LSD (or “acid”), psilocybin (or “magic mushrooms”), and MDMA (or “ecstasy”) has repeatedly shown that the therapeutically beneficial...

Reconsidering evidence for psychedelic-induced psychosis: An overview of reviews, a systematic review, and meta-analysis of human studies

European Psychiatry April 1, 2025 Michel Sabé 3 citations

Introduction Persons with schizophrenia are currently excluded from psychedelic-assisted therapy due to concerns about psychedelic-induced acute or persistent psychotic symptoms. However, meta-analytic evidence of the precise risk for psychedelic-induced de novo and exacerbation of psychosis in people with pre-existing psychotic disorders is lacking. Objectives We conducted an overview of...

De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli

Microbial Biotechnology April 1, 2025 Zhangrao Huang, Yongpeng Yao, Rong Di et al. 12 citations

ABSTRACT Psilocybin, a tryptamine‐derived alkaloid, has been granted Breakthrough Therapy designation by the U.S. FDA for treatment‐resistant depression, underscoring its clinical importance. Therefore, sustainable and economic production is urgently needed. Manufacturing of psilocybin in Escherichia coli has drawn great attention. However, due to the low expression and activity of the...

DOI: 10.1111/1751-7915.70135 (opens in new tab) Psilocybin Escherichia coli Tryptamine Biochemistry +2

Is the Rosary Still Relevant? Exploring its Impact on Mental Health and Well-Being: A Multinational Study.

Journal of Religion and Health April 1, 2025 Lluis Oviedo, Berenika Seryczyńska, Magdalena Jelińska et al. 2 citations

The study of benefits linked to meditation and prayer has provided a considerable amount of empirical evidence revealing their positive influence on health, coping, resilience and flourishing. The practice of praying Rosary has drawn much less attention in academic circles, even if it could probably be enlisted with other forms of meditation and prayer with similar positive effects. The present...

Effects of mindfulness-based stress reduction training on the negative emotions and social functioning of patients with laryngeal cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico April 1, 2025 Lingxue Yin 5 citations

To explore the influence of mindfulness-based stress reduction (MBSR) training on the negative emotions and social functioning of patients with laryngeal cancer post-operation. Sixty-five patients with laryngeal cancer admitted to our hospital from January 2017 to December 2019 were selected and divided into an observation group of 33 cases and a control group of 32 cases according to the...

DOI: 10.1007/s12094-024-03622-1 (opens in new tab) Full text (opens in new tab) Laryngeal cancer Negative emotions Nursing intervention Social functioning