Neuroscience: Special K gets an 'A'.
Jovin R Jacobs, Adam D Douglass
Current Biology April 21, 2025 DOI: 10.1016/j.cub.2025.03.006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Zebrafish |
| Intervention | Ketamine |
| Keywords | Mental health Antidepressants Behavioral research Pharmacology |
| Key points | Ketamine promotes long-term improvements in behavioral persistence in a zebrafish model of depression through a novel mechanism. |
Abstract
A hallmark of depression is a tendency to become passive when faced with overwhelming challenges. A recent study models this phenomenon in zebrafish and discovers a novel mechanism by which the antidepressant drug ketamine promotes long-term improvements in behavioral persistence.
Citations in the library
Cites 4
- Structural neural plasticity evoked by rapid-acting antidepressant interventions. Nature Reviews Neuroscience February 1, 2025
- Targeting metaplasticity mechanisms to promote sustained antidepressant actions. Molecular Psychiatry April 1, 2024
- Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance. Neuron February 5, 2025
- NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses Nature June 15, 2011