Use of selective serotonin reuptake inhibitor (SSRI) antidepressants has been associated with reduced intensity of emotional experience. Conversely, some research has shown that use of psilocybin in patients with depression leads to an increase in responsiveness to emotional face stimuli, suggesting that the psychedelic generates a transient elevation in mood. Investigators conducted a...
ABSTRACT This study aimed to validate the Italian version of the Multiscale Dissociation Inventory (MDI-ITA) and to assess its psychometric properties in a non-clinical sample. The MDI was translated and culturally adapted following established guidelines. A total of 439 Italian-speaking adults participated in the study and filled out the MDI-ITA and other assessment tools for dissociation...
Ketamine is a dissociative anesthetic used in subanesthetic doses with analgesic and anti-depressive properties. However, its mechanistic effects on neuronal signaling and circuit function remain underexplored. We address this shortcoming by employing multi-neuronal imaging in the simple nematode C. elegans that allows measurement of neuron activity across the animal's entire head with...
Abstract Background Major depressive disorder (MDD) is a multifactorial and heterogeneous disorder that affects around 280 million individuals worldwide, with approximately 80 million experiencing treatment-resistant depression (TRD). Neuronal hypotrophy and axon hypomyelination in the prefrontal cortex (PFC) are hallmark features of MDD, highlighting the need for treatments that address these...
Forty per cent of major depression patients are resistant to antidepressant medication. Thus, it is necessary to search for alternative treatments. Melatonin (N-acetyl-5-hydroxytryptamine) enhances neurogenesis and neuronal survival in the adult mouse hippocampal dentate gyrus. Additionally, melatonin stimulates the activity of Ca2+/Calmodulin-dependent Kinase II (CaMKII), promoting dendrite...
Consciousness is the highest mental function that integrates attention, memory, individual experience, emotions, and all modalities of perception, information processing and other manifestations of higher nervous activity of a person. This research was aimed to theoretically substantiate the functional connection of the brain alpha regulatory system with the modulation of conscious activity and...
Abstract Mindfulness-based art therapy (MBAT) is an interdisciplinary intervention that integrates mindfulness techniques with art activities. While previous research has examined MBAT’s effectiveness in reducing depressive symptoms, little is known about the temporal dynamics of change during participation. This study explored session-to-session changes in mindfulness, rumination, and affect...
Abstract Background Ketamine, a rapidly acting antidepressant, requires dosing in clinic because of strong symptoms of dissociation and sedation after IV/IN dosing. This need for dosing in clinic limits capacity to treat patients with Treatment Resistant depression (TRD). We hypothesize that ketamine formulations that maximize ketamine’s first pass metabolism and delay absorption will have...
Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. It has a slow and insidious onset, mainly manifested as sensory and motor dysfunction, and increases susceptibility to psychological problems such as anxiety and depression, seriously affecting the quality of life of patients. The current treatment strategies focus on effective metabolic management...
CureusAugust 1, 2025Lindsay A Turmelle, Carl Chotas
Nitrous oxide, commonly known as "laughing gas," has been widely used as a medical and dental sedative for centuries. Despite its recognized therapeutic applications, there has been a concerning rise in its recreational use, particularly among young adults. This trend has led to an increase in associated toxicities, including neurological, hematological, and psychiatric complications. This is a...