Scientific ReportsFebruary 28, 2026Patryk Główczyński, Paweł Dębski, Karina Badura-Brzoza
Spirituality and religiosity are increasingly examined as factors relevant to mental health, yet less is known about individualized nonreligious forms of spiritual practices. In this cross-sectional study, we investigated associations between spirituality, religious affiliation, non-religious forms of spiritual practices (NFSP) and symptoms of anxiety and depression in 1240 young adults aged...
Background/Objectives: Mindfulness-Based Cognitive Therapy (MBCT) is a well-documented treatment option for chronic pain. However, few studies have examined the emotional state experienced by participants with chronic pain during the sessions. This study aimed to assess the trajectory of mood experiences in an MBCT program and evaluate the effect on temporal mood state. Methods: The Temporary...
Background: Opioid receptors are a commonly used target for treatment of pain conditions. Most opioids used in therapy are linked to adverse effects such as tolerance, dependence, and respiratory depression. Indole alkaloids acting on opioid receptors may provide a novel molecular mechanism to confer analgesic effects. Results: Indole alkaloids such as ibogaine and mitragynine act on μ-opioid...
The rapid expansion of psychedelic research has opened significant pathways of opportunity in treating mental health disorders. Participants in recent clinical trials consistently report mystical-type experiences during dosing sessions, and some scholars posit that such experiences themselves help mediate clinical improvements in depression, PTSD, anxiety, and substance use disorders. These...
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide, including in Indonesia. Patients with CAD frequently experience psychological burdens such as stress, anxiety, and depression, which negatively affect their quality of life and disease prognosis. At the community level, particularly in Puskesmas Lubuk Buaya, cases of coronary heart disease remain...
IMPORTANCE: As psychedelic-assisted therapies gain clinical legitimacy, their cultural portability remains underexamined. While promising results have emerged from trials on existential distress in life-limiting illness, most protocols reflect Euro-American values. The expansion of these therapies calls for a pivot toward cultural humility and renewed attention to what constitutes a "good...
Objectives The .b (“dot be”) mindfulness program aims to reduce both internalizing and externalizing risks and to enhance well-being among adolescents. A UK-based feasibility study (FS) reported significant improvements in depressive symptoms, stress, and well-being, whereas a large-scale randomized controlled trial—the UK-based MYRIAD study (MS) found no improvements and even some negative...
As accumulating evidence suggests the antisuicidal properties of ketamine, elucidating its underlying mechanisms and predictors of treatment response has become crucial. Whether a combination of clinical markers can enhance the prediction of the antisuicidal response to ketamine remains unclear.Using data from our previous randomized placebo-controlled and open-label trials, this post hoc...
Objectives: This study describes the collaborative design and implementation of the Indigenous MIND (IM) program, a culturally adapted mindfulness intervention developed in partnership with Indigenous communities in the USA. The aim was to explore the program's acceptability and cultural resonance and to document the processes by which IM evolved in each of our partner communities and explore...
Psychological stress not only undermines quality of life for people with cancer but also fuels tumor growth. Emerging evidence from the nascent field of cancer neuroscience suggests that adrenergic signaling from direct tumor-neuron interactions drives cancer progression, resistance to treatment, and worse outcomes. Cancer neuroscientists are increasingly seeking to repurpose psychoactive...