After completing this activity, participants should be able to: 1. Describe the pharmacological mechanism of dextromethorphan/bupropion as an oral NMDA receptor antagonist and σ-1 agonist paired with a CYP2D6-inhibiting NDRI, explain how bupropion's CYP2D6 inhibition enhances dextromethorphan's bioavailability and extends its half-life ~3-fold, and identify its two FDA-approved indications —...
Methamphetamine (METH, "Crystal Meth") and 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are two types of substituted amphetamines that share structural-chemical similarities but exhibit contrasting acute and chronic effects including addictive liability. Tryptophan (TRY) pathways are involved in pleiotropic physiological functions at the interface of brain-body connections. Preclinical...
May 20, 2026I. Ivlev, M. Pappas, Tamara P. Cheney et al.
Objective. To evaluate the effectiveness of mindfulness-based interventions (MBIs) and Acceptance and Commitment Therapy (ACT) for mental health and well-being of children and adolescents with and without anxiety, depression, and chronic health conditions. Data sources. Ovid MEDLINE, PsycINFO, Cochrane Library, and ERIC (2009-April 21, 2025); reference lists of relevant reviews. Review methods....
BACKGROUND: Mindful eating interventions target behavioral and emotional processes involved in eating, but most structured programs have been evaluated in English-speaking settings and often compared with passive controls. This randomized controlled trial assessed the effectiveness of the Mind-Eat program, a structured mindfulness-based intervention, versus treatment as usual consisting of a...
Young adult cancer survivors (YACS; 18-39 years old) face ongoing physical and psychosocial sequelae. The REDEFINE study tested the feasibility of mindfulness-based stress reduction (MBSR) using a randomized design. This secondary mixed-methods analysis examined whether qualitative mindfulness reflections were associated with meaningful changes in Patient Reported Outcomes Measurement...
This chapter is designed to offer a comprehensive overview of five core psychedelic medicines—ketamine, psilocybin, MDMA, LSD, and ayahuasca—highlighting their distinct pharmacological properties, cultural origins, therapeutic applications, and clinical research. Although each substance offers a unique entry point into expanded states of consciousness, they share a common potential to catalyze...
Negative emotions affect driving safety. The anxiety of special vehicle drivers caused by stress increases the risk of traffic accidents. It is particularly important to take necessary trainings, and mindfulness training may be an effective measure. However, few studies have addressed these issues. To fill this gap, this study employs quasi-experimental research methods to investigate the...
The term “Om” has been used as a chant in the Sanatan tradition as a beneficial Mantra for maintaining a sound mind in a sound body. This word has been in use extensively in meditation and Yoga. This research aimed to delve into the profound importance of ‘Om’ and the effects of chanting this Mantra on individual well-being, encompassing socio-cultural, physical and psycho-social dimensions. To...
Derecho y cambio social.May 18, 2026Paulo Cesar Moreira, Terezinha Das Graças Laudares, Stephânia de Oliveira Laudares Moreira et al.
This article establishes a deep comparative analysis between the dynamics of transference in Neo-Pentecostal healing rituals and the practice of contemporary psychoanalytic clinics. The starting point of the investigation focuses on specific clinical manifestations, such as somatization and depression, seeking to demonstrate how the so-called "symbolic efficacy" acts in the remission of...
Ketamine, initially developed as a dissociative anaesthetic, has seen expanding therapeutic applications, in managing treatment-resistant depression and chronic pain. However, its psychoactive properties have also been associated with a significant rise in recreational use globally. Chronic, high-dose recreational ketamine use is associated with dependence potential and a spectrum of long-term...