Journal of Affective Disorders
April 15, 2026
Gia Han Le, Sabrina Wong, Danica E. Johnson et al.
4 citations
Ketamine and esketamine exhibit rapid antidepressant effects in persons with treatment-resistant depression (TRD) and bipolar depression (TRBD). However, the synaptic mechanisms governing dose, frequency, and durability of response remain unclear. This review aims to evaluate the dosing parameters, including minimum dose and optimal dosing intervals, that reliably induce or maintain long-term...
Frontiers in Psychiatry
April 13, 2026
Craig F. Ferris
For the past half-century, psychiatric drug development has largely focused on tweaking neurotransmitter receptors and chemical pathways. Yet despite billions of dollars invested and major advances in neuroscience, truly innovative treatments for mental illness remain scarce. Disorders like depression, schizophrenia, and post-traumatic stress disorder (PTSD) continue to be managed with drugs...
L'Encephale
April 9, 2026
Amel Bouloufa, Sarah Delcourte, Thomas Delannay et al.
Major depressive disorder (MDD) represents a colossal worldwide burden of health, affecting more than 350 million individuals. While traditional antidepressants with mechanisms of action at the serotonin, dopamine, or norepinephrine pathways are routinely prescribed, approximately one-third of patients fail to achieve adequate remission and develop treatment-resistant depression (TRD). This...
Frontiers in Psychiatry
April 7, 2026
Ravi Philip Rajkumar
Post-traumatic stress disorder (PTSD) is a chronic mental illness that occurs following exposure to traumatic stressors such as combat, disasters, or assault. It is characterized by a triad of reexperiencing of the trauma, avoidance of triggers for such recollections, and increased vigilance towards threats (1). In 1992, Judith Herman described a variant of PTSD that occurred in persons who had...
Phenomenology and the Cognitive Sciences
April 6, 2026
Thomas Fuchs
1 citation
The feeling of being alive points to an intricate connection between the organic process of life and foundational subjective experience, or between life and experience ( Leben and Erleben ). Based on this premise, I argue that self-experience cannot be understood as an internal mental space or a “self-model” that could be produced and localized in the brain, but rather that it is a...
FOCUS: The Journal of Lifelong Learning in Psychiatry
April 1, 2026
Rachel Fremont, Marcella Corwin, Greta Kandel et al.
Over the past 25 years, the field of psychiatry has seen a rapid expansion of ketamine treatment services offered for the off-label management of depression, anxiety, and other psychiatric disorders as well as the U.S. Food and Drug Administration's approval of intranasal esketamine, the S-enantiomer of ketamine, for treatment-resistant depression and suicidal depression. In this review, the...
Scientific Reports
April 1, 2026
David B. Feldman, Shauna L. Shapiro, Diane E Dreher
Mindfulness and hope are both associated with well-being, yet their orientations—present-focused awareness versus future-directed striving—are seemingly at odds. Moreover, limited research addresses them simultaneously. We investigated the relationship between mindfulness and hope, assessing their associations with psychological well-being. A cross-sectional survey of 145 undergraduates (Mage =...
Journal of Affective Disorders
April 1, 2026
Kayla M Teopiz, Gia Han Le, Sabrina Wong et al.
Extant literature suggests that anhedonia, defined as a loss of the ability to feel pleasure or interest, is subserved by dysregulation of reward processing in the central nervous system. Dextromethorphan (DXM), an uncompetitive N-Methyl-d-Aspartate (NMDA) receptor antagonist and sigma-1 (σ1) receptor agonist, is a glutamatergic modulator with antidepressant properties. The effect of DXM on...
Mini-Reviews in Medicinal Chemistry
March 24, 2026
Shivaputra A Patil, Holly C Hunsberger
Psilocybin, chemically known as (4-phosphoryloxy-N, N-dimethyltryptamine, 4-PODMT), is derived from the psychoactive mushroom genus, Psilocybe. Of the four active metabolites, psilocin readily enters systemic circulation. The psychoactive effects of psilocin are thought to arise through partial agonist effects at the 5-HT2A receptor. Psychedelic drugs, including psilocybin, are having a...
Psychopharmacology
March 16, 2026
Ye Li, Qilong Cheng, Guoxin Lin et al.
RATIONALE: Major Depressive Disorder (MDD) is a global public health burden, with traditional monoaminergic antidepressants facing critical limitations including slow onset, adverse side effects, and high rates of treatment resistance (TRD). Ketamine, a rapid-acting agent with sustained antidepressant effects, has revolutionized depression treatment paradigms but challenges conventional...