Cognition & Emotion
June 12, 2026
Jenna M Wilson, Jerin Lee, JoNell Strough et al.
Mindfulness has been linked to lower psychological distress. Yet, it remains unclear how, or the mechanism(s) by which, mindfulness reduces psychological distress, particularly during times of heightened, prolonged stress. The present research utilised secondary analysis of data from two independent studies to 1) assess whether greater trait mindfulness protected U.S. adults against...
Mental Health Weekly
June 12, 2026
Valerie A. Canady
For many patients with major depressive disorder, reaching remission — not just partial response — can significantly alter the course of illness, lowering the risk of relapse and improving day‐to‐day functioning. Yet that goal remains elusive for those with treatment‐resistant depression (TRD), where repeated medication failures, comorbid conditions, and lingering symptoms complicate care. Data...
Canadian Journal on Aging
June 2, 2026
Andréanne Simard, Isabelle F-Dufour, Sonia Goulet et al.
Les interventions basées sur la pleine conscience (IBPC) sont reconnues comme des approches pertinentes auprès de personnes vieillissantes à risque de déclin cognitif. Toutefois, peu d'études ont exploré l'expérience vécue de participants présentant un déclin cognitif accompagné de symptômes anxiodépressifs. Cette étude qualitative vise à comprendre l'expérience de 13 adultes de 55 ans et plus...
American Journal of Health Promotion
June 1, 2026
Jungjoo Lee, Junhyoung Kim
PurposeThis study evaluated the feasibility of incorporating Virtual Reality (VR) technology into meditation exercises and using Electrocardiogram (ECG) devices for emotion regulation assessment. It also explored changes in emotion regulation, depression, and anxiety among participants.DesignA single-arm feasibility study.SubjectsPsychiatric hospital inpatients diagnosed by physicians with...
Contemporary Clinical Trials Communications
June 1, 2026
Anne Malaktaris, Niloofar Afari, Pollyanna Casmar et al.
Chronic pain with psychological comorbidity, especially posttraumatic stress disorder (PTSD) and/or depression, is a prevalent and costly problem, especially among Veterans. Compassion meditation (CM) is a meditative practice that focuses on developing attentional regulation and the intention to assuage suffering. CM-based approaches show promise in ameliorating physical and mental health...
International Journal of Psychiatry in Clinical Practice
June 1, 2026
Damian Swieczkowski, Aleksander Kwaśny, Michal Pruc et al.
To explore sex, racial and ethnic disparities in esketamine clinical trials for mental health disorders registered on ClinicalTrials.gov. We conducted a registry-based cross-sectional analysis of interventional esketamine trials with results posted on ClinicalTrials.gov (cut-off date: 10 February 2025). Using predefined eligibility criteria, two investigators independently extracted and...
Future oncology
June 1, 2026
Minqing Huang, Guiling Huang, Fang Wang et al.
Chemotherapy-induced nausea and vomiting, together with depression and anxiety, are common and distressing complications in patients with colorectal cancer that seriously impair quality of life and treatment adherence. This study explored the efficacy of mindfulness-based stress reduction (MBSR) in relieving chemotherapy-related physical and psychological distress. This retrospective cohort...
Pharmaceuticals
May 31, 2026
Wenting Zhang, Xin Guo, Jiping Zhang et al.
Background: Ketamine is a rapid-acting antidepressant for major depressive disorder; however, its effects are short-lasting and associated with neurotoxic side effects. Thus, identifying strategies to prolong its antidepressant effects is of critical importance. It has been shown that Dajianzhong Decoction (DJZT) prolongs the antidepressant effects of ketamine through modulation of the gut...
Journal of Medical Internet Research
May 14, 2026
Giovanni Ramos, Amanda K Montoya, Adrian Aguilera et al.
Background: Racially and ethnically minoritized individuals (REMs) who experience discrimination are at risk of developing stress, anxiety, and depression, and digital mental health interventions (DMHIs) can make evidence-based treatments such as mindfulness available to these groups. However, REMs are significantly underrepresented in the overall DMHI and mindfulness-based DMHI literature,...
ACS Chemical Neuroscience
May 6, 2026
Maxemiliano V. Vargas, Cassandra J. Hatzipantelis, Lee E. Dunlap et al.
Recent clinical evidence suggests that racemic 3,4-methylenedioxymethamphetamine (MDMA) might be useful for treating a range of neuropsychiatric diseases including post-traumatic stress disorder (PTSD) and depression. However, concerns about its abuse potential stemming from its monoamine releasing properties have hampered its clinical development. Thus, safer analogues of racemic MDMA with...