European Neuropsychopharmacology
April 2019
Sabine Aust, Matti Gärtner, Laura Basso et al.
About 20 to 30 percent of patients with Major Depressive Disorder (MDD) do not respond to standard treatment and are considered treatment-resistant. The N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant MDD, but it is unknown whether its acute psychological effects are related to the later antidepressant...
Cutting Edge Psychiatry in Practice
March 31, 2019
James Stone
There has been considerable interest in the potential of ketamine as a novel antidepressant with a unique mechanism of action. In a number of small trials, ketamine has been shown to lead to reductions in depressive symptoms within hours of administration in patients with symptoms that are otherwise refractory to treatment, with the antidepressant response lasting for days. Although the...
American Journal of Psychiatry
March 29, 2019
J. Phillips, S. Norris, Jeanne Talbot et al.
416 citations
OBJECTIVE Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with treatment-resistant depression, which may be prolonged by repeated administration. The purpose of this study was to evaluate the antidepressant effects of a single ketamine infusion, a series of repeated ketamine infusions, and prolongation of response with maintenance...
March 23, 2019
A. Azam, V. Latman, J. Katz
BACKGROUND Mindfulness meditation is a commonly used psychological intervention for pain, mood, and anxiety conditions, but can be challenging to practice when dealing with severe symptoms without proper training experience. The Mindfulness Meditation App (MMA) is a supportive training tool specifically developed for the present study, to aid in the practice of mindful breathing using a...
Frontiers in Psychology
March 8, 2019
F. Parmentier, Mauro Garcia-Toro, Javier García-campayo et al.
The present study examined the effects of mindfulness on depression and anxiety, both direct and indirect through the mediation of four mechanisms of emotional regulation: worry, rumination, reappraisal and suppression. Path analysis was applied to data collected from an international and non-clinical sample of 1151 adults, including both meditators and non-meditators, who completed an online...
American Journal of Geriatric Psychiatry
March 1, 2019
Sophia Escobar
Introduction Approximately 10-20% of older adults treated in primary care settings suffer from symptoms of depression and/or anxiety. As our population ages, the number of older adults in primary care increases, and the urgent need to find cost-effective and efficient alternative therapies become crucial. The present RCT study aim was to investigate the effect of mindfulness-based cognitive...
PsyPag Quarterly
March 1, 2019
Baland Jalal, Andrea Romanelli, Devon E Hinton
A recent study found that over a third of Italians (in Abruzzo) believe their sleep paralysis (SP) might be caused by the Pandafeche – a supernatural creature (Jalal et al., 2015). Research also suggests that SP in Italy has been shaped by local cultural beliefs, which have worsened the experience (e.g. longer paralysis and excessive fear) and made it more frequent; a mind-body interaction. In...
Journal of Clinical Psychopharmacology
March 1, 2019
Kelly A. Bryant, Murat Altinay, Nora Finnegan et al.
Abstract Purpose There is an immediate need for more sustainable, effective therapies for treatment-resistant depression in patients who do not respond to traditional psychopharmacology. The aim of this study was to determine the efficacy and safety of intravenous ketamine infusions on the elderly population by using a case series of 6 geriatric patients with treatment-resistant depression....
Journal of the American Pharmacists Association
March 1, 2019
J. Perepelkin, Kristen Antunes, Luke Boechler et al.
OBJECTIVE The objective of this study was to assess the impact of mindfulness meditation offered in a community pharmacy on patients with current anxiety or a history of anxiety, depression, or both. SETTING Community pharmacy clinical space located in a grocery store. PRACTICE DESCRIPTION An 8-week, once-per-week mindfulness meditation program for patients with anxiety or depression. PRACTICE...
Journal of Affective Disorders
March 1, 2019
M. Carpena, P. Tavares, C. Menezes
BACKGROUND Evidence shows high prevalence of depression and anxiety symptoms among university students. This study investigated whether a meditation-based program would help reducing these symptoms in this population. METHODS Non-randomized controlled trial investigating the effects of a six-week focused meditation training on depression (Beck Depression Inventory) and anxiety (Beck Anxiety...