Contemporary Clinical Trials
February 1, 2019
S. Mathew, S. Wilkinson, Murat Altinay et al.
54 citations
Major depressive disorder (MDD) is the most common mental illness and the leading cause of disability worldwide. Electroconvulsive therapy (ECT) is the most effective treatment for MDD and the gold-standard therapy for treatment-resistant depression (TRD), yet it remains underutilized due to factors such as limited availability, stigma, and concerns about cognitive side effects. Ketamine has...
Psychiatry Research Neuroimaging
January 30, 2019
Allison C. Nugent, Kathleen E. Wills, Jessica R. Gilbert et al.
Preclinical and clinical evidence has demonstrated that ketamine has rapid antidepressant effects. Studies using pre-treatment with an AMPA inhibitor suggest that enhancing AMPA throughput is crucial to ketamine's effects, including increases in both basal and evoked gamma power. This study sought to replicate previous findings of increased gamma response to a somatosensory stimulus at 230 min...
International Journal of Mental Health Nursing
January 17, 2019
Simon Y. W. Li, D. Bressington
Mindfulness-based stress reduction (MBSR) has been widely used to improve various physical and mental conditions. Studies show the intervention is particularly effective in alleviating depression, anxiety, and stress in working-aged adults. No recent systematic review has focused on the use of MBSR in older adults. This study aims to examine the effects of MBSR intervention on depression,...
ScholarWorks -A service of University of Vermont Libraries
2019
M. Knapp
Mental health is a major burden on residents of Vermont. Access to care is the most commonly cited cause. An evidence-based pamphlet was designed to empower providers to quickly and easily help patients start a meditation practice to help address such concerns.
Psychology, Health & Medicine
January 2019
Jia-Yuan Zhang, Yu-Xia Cui, Yu-Qiu Zhou et al.
Low well-being is common among Chinese pregnant women but few effective interventions currently exist to improve prenatal stress and negative emotions. Mindfulness-based stress reduction (MBSR) has been proved to be effective in reducing stress and rarely studies were focused on Chinese pregnant women. The aim of the current paper is to investigate the effects of 8-week MBSR on prenatal stress,...
Archives of Physical Medicine and Rehabilitation
January 2019
Jasmine Heath Hearn, Imogen Cotter, Katherine Anne Finlay
To explore the feasibility and efficacy of web-based mindfulness training for carers of people with spinal cord injury (SCI). Randomized controlled feasibility study with 3-month follow-up. Community setting. Spouses or family caregivers (N=55) of people with SCI and chronic neuropathic pain were recruited via the direct care team and advertisements. Participants were older than 18 years (no...
Chronic Stress
2019
Ginetta Collo, Laura Cavalleri, Emilio Merlo Pich
The mechanisms underlying the antidepressant effects of ketamine in treatment-resistant depression are only partially understood. Reactivation of neural plasticity in prefrontal cortex has been considered critical in mediating the effects of standard antidepressants, but in treatment-resistant depression patients with severe anhedonia, other components of the affected brain circuits, for...
Pharmacology, Biochemistry, and Behavior
2019
Nian-nian Huang, Dongyu Hua, Gaofeng Zhan et al.
ABSTRACT Ketamine, an N‐methyl‐d‐aspartic acid receptor (NMDAR) antagonist, elicits rapid‐acting and sustained antidepressant effects in treatment‐resistant depressed patients. Accumulating evidence suggests that gut microbiota via the gut‐brain axis play a role in the pathogenesis of depression, thereby contributing to the antidepressant actions of certain compounds. Here we investigated the...
Journal of Gerontology
2019
R. K. Pirkalani, Leyly Ramezan Saatchi, Mahsa Majd
Introduction: The world's population is rapidly aging. Mental health is vital in the elderly. The purpose of this study was to investigate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on Depression, Death Anxiety and Life Expectancy in the Elderly. Method: This study is an experimental research with pre and post-test approach. The statistical population was all elderly women...
International Journal of Physiology
2019
E. Syamala, P. Roy, K. Sailesh et al.
The current study was undertaken to observe the effectiveness of Raja Yoga Meditation on depression, anxiety and stress in females with premenstrual syndrome. In the present study, a total of 8 participants were recruited and the participants served as self-controls. After recording the baseline values in premenstrual period (7 days before menstruation) of menstrual cycle, participants were...