There has been considerable interest in the potential of ketamine as a novel antidepressant with a unique mechanism of action. In a number of small trials, ketamine has been shown to lead to reductions in depressive symptoms within hours of administration in patients with symptoms that are otherwise refractory to treatment, with the antidepressant response lasting for days. Although the...
In this paper we discuss the phenomenon of the presence of auditory hallucinations in otherwise asymptomatic patients. We discuss the significance of these patients, both as persons who do not suffer from disease, and as an at risk group for patients who later may develop psychosis. The genetic implications of this phenomenon, and the implications for the aetiology, nosology and treatment of...