Advances in experimental medicine and biology
2021
José Carlos Bouso, Genís Ona, Rafael G. Dos Santos et al.
6 citations
The volume of research on the therapeutic use of psychedelic drugs has been increasing during the last decades. Partly because of the need of innovative treatments in psychiatry, several studies have assessed the safety and efficacy of drugs like psilocybin or ayahuasca for a wide range of mental disorders, including major depression. The first section of this chapter will offer an introduction...
Psychotherapy and Psychosomatics
2021
Samuel t. Wilkinson, Taeho greg Rhee, Jutta Joormann et al.
102 citations
<b><i>Introduction:</i></b> Ketamine has emerged as a rapid-acting antidepressant. While ongoing treatment can prevent relapse, concerns exist regarding long-term exposure. <b><i>Objective:</i></b> We conducted a randomized trial to examine the feasibility and efficacy of cognitive behavioral therapy (CBT) following intravenous ketamine in treatment-resistant depression (TRD)....
International Journal of Advanced Research in Medicine
2021
Yogesh Kumar Chahar
Major depressive disorder (MDD) has become a health crisis of epidemic proportions in the modern world. One in six individuals in the world is experiencing an episode of major depression in his or her lifetime, and it is estimated that major depression will rank second after cardiac disease as a cause of international medical morbidity by the year 2020. Depression is associated with greater...
Brazilian Journal of Development
2021
Vagner Fagnani Linartevichi, Matheus Gonzales Froza, Rafael de Morais Cury et al.
4 citations
A depressão, ou Distúrbio Depressivo Maior (DDM), é uma enfermidade que acomete cerca de 322 milhões de pessoas e pode ser debilitante, havendo uma grande demanda para tratamentos eficazes no manejo desta doença. O presente estudo teve por objetivo organizar uma revisão de artigos publicados acerca do uso do composto psilocibina, a fim de averiguar seu potencial terapêutico no tratamento de...
The International Journal of Neuropsychopharmacology
December 29, 2020
Mu-Hong Chen, Wan-Chen Chang, Wei-Chen Lin et al.
28 citations
Frontostriatal disconnectivity plays a crucial role in the pathophysiology of major depressive disorder. However, whether the baseline functional connectivity of the frontostriatal network could predict the treatment outcome of low-dose ketamine infusion remains unknown. In total, 48 patients with treatment-resistant depression were randomly divided into 3 treatment groups (a single-dose...
Appetite
December 26, 2020
Ti Hsu, Catherine A Forestell
Emotional eating is defined as the tendency to increase food consumption in order to modify negative emotional states. Theories on emotional eating attribute its cause to inadequate emotion regulation, specifically an inability to draw awareness to and accept distress. Mindfulness, or the ability to pay attention to and accept internal and external experiences, is thought to attenuate the...
HRB Open Research
December 16, 2020
Bronagh Gallagher, Meabh Foley, C. Slattery et al.
6 citations
Background: Depression is a common psychiatric disorder that has become the leading cause of disability worldwide. The standard medical care for depression over the past 50 years has focused on monoamine neurotransmitters. These treatments can take weeks to take effect, highlighting the need for novel treatment strategies. One such approach may be ketamine. Ketamine acts as an antagonist of the...
Journal of Psychiatric Research
December 11, 2020
Jiaqi Xiong, Orly Lipsitz, David C J Chen-Li et al.
122 citations
The efficacy of ketamine in reducing suicidal ideation (SI) has been previously reported. We aimed to evaluate acute anti-SI effects of single-dose ketamine in different formulations/routes of administration by pooling results from randomized controlled trials (RCTs). A systematic search was conducted on Cochrane, Embase, Medline, and PubMed from inception to July 1st, 2020. Studies were...
Brain Sciences
December 11, 2020
Jakub Słupski, Wiesław Jerzy Cubała, Natalia Górska et al.
7 citations
Changes in serum copper concentration are observed in patients with depressive symptoms. Unmet needs in contemporary antidepressant treatment have increased interest in non-monoaminergic antidepressants, such as ketamine, an anaesthetic drug that has demonstrated a rapid antidepressant effect in patients with treatment-resistant depression (TRD). The purpose of this study was to examine whether...
Journal of Clinical Medicine
December 9, 2020
Marine Ambar Akkaoui, Michel Lejoyeux, Marie-Pia d'Ortho et al.
Chronic nightmares are very common in psychiatric disorders, affecting up to 70% of patients with personality or post-traumatic stress disorders. In other psychiatric disorders, the relationships with nightmares are poorly known. This review aimed to clarify the relationship between nightmares and both mood and psychotic disorders. We performed a systematic literature search using the PubMed,...