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HRB Open Research

ISSN 2515-4826

1 paper in the library · 6 citations · publishing 2020

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Ketamine as an adjunctive therapy for major depression - a randomised controlled pragmatic pilot trial (Karma-Dep Trial)

HRB Open Research December 16, 2020 Bronagh Gallagher, Meabh Foley, C. Slattery et al. 6 citations

Background: Depression is a common psychiatric disorder that has become the leading cause of disability worldwide. The standard medical care for depression over the past 50 years has focused on monoamine neurotransmitters. These treatments can take weeks to take effect, highlighting the need for novel treatment strategies. One such approach may be ketamine. Ketamine acts as an antagonist of the...