Depression is a common psychiatric disorder, with a higher prevalence in women than in men, and has been increasingly associated with disturbances in female reproductive health. In particular, depressive conditions may impair ovarian function and compromise oocyte quality, thereby contributing to reproductive disorders. Ketamine is a clinically effective antidepressant. However, its potential...
Psilocybin-assisted therapy may be a promising new treatment for treatment-resistant depression. We examined the feasibility of administering a single 25-mg dose of psilocybin or placebo with psychological support in a randomized controlled trial design with 6 weeks of follow-up. A two-arm, double-blind, randomized, placebo-controlled feasibility trial was conducted at one National Health...
Background Clinical nurses are essential to healthcare, but they experience high rates of depression, anxiety, and sleep disturbances. This study examined the relationships among occupational stressors, sleep problems, mindfulness, and psychological well-being in hospital nurses. Methods In a cross-sectional study of 416 clinical nurses from a tertiary general hospital in China, we assessed...
Abstract Introduction Major depressive disorder (MDD) is characterized by dysfunction in higher-order cortical regions involved in emotional and cognitive processes; however, its neurobiological basis remains unclear. Pharmacological treatments, including esketamine and sertraline, produce rapid antidepressant effects. We investigated the local intrinsic neural dynamics underlying these...
The COVID-19 pandemic highlighted a critical need for effective population mental health approaches to target the most prevalent disorders (eg, depression) during periods of elevated community distress. The effectiveness of remotely delivered and web-based interventions should be investigated to identify and innovate high-quality models for population mental health service delivery. The primary...
This study examined the psychological impact of racial microaggressions among racially minoritized young adults. Specifically, the study tested the direct and indirect effects of racial microaggressions on purpose of life through depressive symptoms, while also considering the buffering effects of mindfulness practices on the relationships between these variables. Using a cross-sectional...
This narrative review examines barriers to Danish patients' timely access to new treatments for treatment-resistant depression, focusing on controversies around esketamine. Delays arise from regulatory complexity, economic constraints and scientific debate over novel psychotropics. The review advocates evidence-based, faster implementation pathways for new treatments to alleviate the overall...
Abstract Background Group mindfulness-based cognitive therapy (MBCT) is recommended for the treatment of subthreshold-to-mild depressive symptoms. Timely access to MBCT, however, is limited by accessibility issues. Self-help MBCT can overcome these issues, but is associated with poorer engagement. Incorporating virtual reality into self-help MBCT (VR-MBCT) may improve engagement, but relatively...
Background: Perinatal depression is a highly common clinical complication. While expert panels advocate for non-pharmacological treatments, the relative benefits of mindfulness-based interventions delivered face-to-face versus through emerging digital platforms have not been examined within a single integrated synthesis that distinguishes the contribution of delivery mode from that of trial era...
Depression remains a significant public health concern worldwide and many individuals do not achieve adequate symptom relief from conventional treatments such as antidepressants and psychological therapies. Interest has therefore increased in alternative interventions, including psilocybin microdosing. This article aimed to critically review the current evidence regarding the use of psilocybin...