BMC Anesthesiology
August 26, 2026
Mao Li, Wen Wen, Xiang Wen
Postoperative depression and anxiety are common in elderly patients undergoing joint replacement surgery and may affect recovery. Esketamine has rapid antidepressant effects, but evidence for combined perioperative use remains limited, particularly in elderly patients undergoing joint replacement surgery. This study evaluated the association between combined perioperative esketamine exposure...
Journal of Affective Disorders
August 26, 2026
Decreased accumbens-amygdala connectivity is associated with sleep improvement in late-life depression following mindfulness-based cognitive therapy.
Healthcare
August 26, 2026
Mostafa A. Sayed Ali, Palanisamy Amirthalingam, Hanan Alshareef et al.
Background/Objectives: This study evaluated the real-world effectiveness and safety of intranasal esketamine plus oral antidepressants compared with venlafaxine-based oral antidepressant therapy in adults with moderate-to-severe treatment-resistant depression (TRD). Methods: This retrospective cohort study used electronic medical records from a mental health hospital between January 2023 and...
Neuropsychiatrie
August 25, 2026
Nicolas Schmelzle, Katrin Neubacher, Paul L. Plener et al.
BACKGROUND: Depressive symptoms and suicidality are highly prevalent in adolescents with early-onset psychosis (EOP) and often remain refractory to standard treatment. While S‑ketamine is an established treatment for treatment-resistant depression in adults (TRD), its use in primary psychotic disorders remains scarce due to risk of exacerbation of psychotic symptoms. CASE PRESENTATION: We...
Biomolecules
August 24, 2026
Agnieszka Pałucha-Poniewiera
The use of animal models to study mental illnesses, such as depression, requires proper standardization and extensive expertise. Achieving good construct, face, and predictive validity in depression models is quite challenging. Currently, only a few environmental models, mostly based on chronic stress, and a limited number of genetic models fulfill these criteria. In the quest for new...
World Journal of Psychiatry
August 19, 2026
Yun-Xia Shi, Bing Qin, Xiao-Xiao Wang et al.
BACKGROUND Lower extremity arteriosclerotic occlusive disease (LEAOD) is a prevalent chronic vascular condition that significantly increases the risk of lower limb dysfunction and depressive symptoms. Mindfulness-based interventions have demonstrated efficacy in improving mood and coping ability in patients with various chronic illnesses; however, their specific impact on the dual burden of...
Frontiers in Pharmacology
August 19, 2026
İlay Buran Kavuran, Ebru Önalan, Zeliha İrem Türk et al.
Background Major depressive disorder (MDD) is associated with multiple pathophysiological mechanisms, including dysregulation of monoaminergic systems, excessive glutamatergic activity, reduced neurotrophic support, inflammation, and oxidative stress. The combination of dextromethorphan, an N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist, with bupropion, a...
International Health Sciences Review
August 18, 2026
Samuel Cândido Freres, Marco Antonio Franco Cançado, Aline Ferreira Catrolio et al.
Treatment-resistant depression (TRD) represents one of the most complex forms of major depressive disorder, characterized by the persistence of clinically significant symptoms despite the performance of appropriate therapeutic interventions. This condition is associated with a worse prognosis, higher risk of recurrence, functional impairment, increased morbidity and mortality, and high...
August 18, 2026
Mary Jackson, Nathaniel Glassy, Janet Bettger
preprint
Primary Question: What specific structural, instructional and clinical components characterize mindfulness-based stress reduction and related interventions that are effective for positively affecting post-stroke depression in the 6 months following an adult’s index stroke? Primary Objective: The objective of this scoping review is to systematically identify and synthesize the existing...
Expert Review of Neurotherapeutics
August 18, 2026
Mario Pinzi, Alessandro Cuomo, Maria Beatrice Rescalli et al.
INTRODUCTION: Acute suicidal ideation in major depressive disorder (MDD) is a psychiatric emergency requiring rapid risk assessment, containment, and treatment. Conventional monoaminergic antidepressants have delayed onset, leaving an interval during which severe depressive distress persists. Intranasal esketamine, a rapid-acting N-methyl-D-aspartate receptor antagonist, is approved for MDD...