Provided herein are novel 3-pyrrolidineindole derivatives as serotonergic psychedelic agents, pharmaceutical compositions, use of such compounds in treating psychosis and mental illnesses such as depression and post-traumatic stress disorder, and processes for preparing such compounds.
Objectives This intervention study aimed to evaluate mindfulness meditation as a method of treatment for cancer outpatients for stress reduction and control of symptoms of depression and to find out effects of socio demographic differences. Method Cancer outpatients were randomly selected on separate clinic dates at the National Cancer Institute of Sri Lanka and were enrolled as cases (n=44)...
Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties. To investigate if subcutaneous racemic ketamine, delivered twice weekly for 4 weeks, reduces anxiety in people with TRD. The Ketamine for Adult Depression Study was a multisite 4-week randomised, double-blind, active...
Ketamine is a promising therapy for treatment-resistant depression due to its rapid onset, although benefits are often transitory, with patients needing maintenance therapy to prevent relapse. Most data supporting ketamine for treatment-resistant depression refers to the intravenous route of administration, leaving alternative routes lacking in data, especially as maintenance regimens....
ABSTRACT Objective This pilot study assessed the feasibility and preliminary effects of an 8-week digital Mindfulness-Based Cognitive Therapy (MBCT) intervention on perinatal depression, mindfulness, well-being, and work motivation among pregnant working women. Methods The intervention included weekly online sessions and mindfulness audio guides. Pre- and post-assessments used the EPDS, TFMQ,...
A landmark systematic umbrella review by University College London researchers published in Molecular Psychiatry found no solid scientific evidence supporting the serotonin theory of depression, challenging the foundational "chemical imbalance" hypothesis underlying SSRI treatment and opening new avenues for alternative therapeutic approaches. This essay examines how the collapse of the...
Background: This study aims to specifically review the efficacy of mindfulness‐based interventions (MBIs) for breast cancer patients undergoing chemotherapy.
Abstract Traumatic brain injury (TBI) can alter day-to-day life. While changes in cognition and physical function are most often cited, emotional disturbances, notably depression, are also common. For individuals who experience depression symptoms, mindfulness-based cognitive therapy (MBCT) may afford the opportunity to address these symptoms by teaching skills to mitigate negative thought...
CNS Spectrums2025Ana Rodríguez Lorente, María Pilar Campos-Navarro, Ángela Gil Montoya et al.
Abstract Objectives This proof-of-concept study aimed to assess the impact of intranasal esketamine (ESK-IN) in brain volume and neurofilament light chain (sNfL) over 6-months in patients with treatment resistant depression (TDR). Methods Seven TRD patients received ESK-IN while continuing oral antidepressants. Clinical evaluations were conducted at baseline, 1, 3, and 6 months, with MRI scans...
Abstract Depression is the leading cause of suicide, and antidepressants and modified electroconvulsive therapy (mECT) are the preferred treatment modalities. Ketamine is an established anesthetic agent and evidence for its use in depression is evolving. Here, we discuss the experience of treating severe depression with intravenous (IV) ketamine. A patient in his mid-forties presented with a...