Szilvia Kresznerits, Ágnes Zinner-Gérecz, Mónika Miklósi et al.
preprint
Abstract Background Non-suicidal self-injury (NSSI) is highly prevalent among individuals with borderline personality disorder (BPD) and is one of the most robust predictors of future suicide attempts and suicide deaths. Access to comprehensive treatments such as dialectical behaviour therapy remains limited. Methods This exploratory study evaluated the feasibility and preliminary outcomes of a...
Yao Coitinho Biurra, Colette Naude, Zoe Coitinho Biurra et al.
preprint
Abstract Background: Pain is biopsychosocial in nature, and international guidelines now emphasize interdisciplinary treatment. Psychotherapeutic interventions such as Mantra Meditation (MM) are being increasingly studied for their potential benefits in pain management. Objectives: To conduct a systematic review and meta-analysis of the evidence for MM in improving biopsychosocial outcomes in...
Aarathi Venkatesan, Holly Krymis, Jenny Scharff et al.
BACKGROUND As the need for effective scalable interventions for mental health conditions such as depression, anxiety, and stress has grown, the digital delivery of mindfulness-based stress reduction (MBSR) has gained interest as a promising intervention in this domain. OBJECTIVE This study aims to evaluate the changes in perceived stress following a 10-week digital MBSR program that combined an...
Igor O. Poluboiartsev
preprint
Abstract Objective This study aims to ascertain the validity and effectiveness of the Mindfulness-Based Stress Reduction (MBSR) technique in reducing stress and preventing emotional burnout among psychiatric nurses, with the goal of introducing it as a resource-efficient intervention in psychiatric medical institutions. Materials and methods From November 1, 2022, to February 28, 2023, we...
Sandra Ledesma-Corvi, Jordi Jornet-Plaza, M. Julia García-Fuster
preprint
Abstract Ketamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in its efficacy. Sex steroids, such as estrogen and testosterone, both in the periphery and locally in the brain, are regarded as important modulators of these sex differences. Therefore, the present study evaluated the role of inhibiting estrogen biosynthesis with...
Gavin Dennett, Bryn Dennett
preprint
The illegal PCP (phencyclidine) has recently undergone a significant transformation. One characterized by the proliferation of structurally similar arylcyclohexylamine analogs. As well as the general increasing infiltration of synthetic opioids. This review synthesizes current relevant pharmacological, psychopharmacological, toxicological, forensic, and epidemiological evidence in the...
Ari Brouwer, Robin Carhart-Harris, Charles L. Raison
preprint
It is a paradox that psychotomimetic drugs can relieve symptoms that increase risk of and cooccur with psychosis, such as attention and motivational deficits (e.g., amphetamines), pain (e.g., cannabis) and symptoms of depression (e.g., psychedelics, dissociatives). We introduce the ideas of psychotomimetic compensation and psychotomimetic sensitization to explain this paradox. Psychotomimetic...
Vinitha Ganesan, Priyam Singh, Ritu Aneja et al.
preprint
Rhythmic breathwork rooted in yogic tradition has been associated with stress reduction, partly through modulation of autonomic balance via increased parasympathetic vagal activity. However, the integrated psycho-neuro-immune mechanisms through which these autonomic shifts translate into downstream immune and molecular changes remain incompletely characterized. We conducted a pilot randomized...
Joaquín García-alandete
preprint
Abstract Self-transcendence can be defined as what goes beyond one’s limitations and difficulties in life in order to serve or connect with something greater. Self-transcendence is related to both mental and physical health in older people, so it is important to have instruments to measure it properly. This study analyzes the psychometric properties of Wong’s Self-Transcendence Measure-Brief...
Navin Cooray, Chetan Gohil, Brendan Harris et al.
preprint
Abstract Mental health disorders affect countless people worldwide and present a major challenge for mental health services, which are struggling with the demand on a global scale. Recent studies have indicated that activity of the brain’s Default Mode Network (DMN) could prove insightful in monitoring patient recovery from depression and has been used as a therapeutic target itself. An...