Anis Murtaza, Reem Altaf, Muzaffar Abbas
preprint
Abstract Schizophrenia (SCZ) is a chronic neuropsychiatric disorder driven by neuroinflammation, microglial overactivation, and pro-inflammatory cytokine dysregulation. Despite antipsychotics, negative and cognitive symptoms remain inadequately treated. This study investigated the therapeutic potential of Chlorogenic Acid (CGA) in a ketamine-induced mouse model of SCZ using integrated in silico...
Gabriel P. A. Costa, Christina Riggione, Christopher Pittenger et al.
Supervised psilocybin services are expanding across the United States, yet how individuals accessing these programs compare with those using psilocybin in the general population is unknown. We conducted a cross-sectional descriptive comparison of Oregon Psilocybin Services (OPS) data from licensed service centers in 2025 (5,935 encounters) and the 2024 National Survey on Drug Use and Health...
Keisuke Suzuki, Yuri Terasawa, Yoshiyuki Nishio et al.
preprint
Cognitive feelings, such as the feeling of knowing, familiarity, presence, reality, confidence, agency, and body ownership, are subjective experiences arising from cognitive processes, playing crucial roles in perception, memory, and decision-making. Despite extensive research across philosophy, psychology, and neuroscience, they have been studied in fragmented ways, lacking a unified...
E.m.s.k Edirisinghe, A.j.w.a.n Wimalasiri, S.S Sirithunga et al.
preprint
Abstract Background Chronic kidney disease (CKD) imposes substantial psychological and sleep-related burdens that are frequently underdiagnosed in low- and middle-income countries (LMICs). Dream characteristics, an understudied marker of psychological state, have not previously been examined in CKD populations in Sri Lanka. This study assessed sleep quality, dream characteristics, and...
Sherif Ganim, Shada Haiadri, Coral Cohen et al.
preprint
Abstract Background Mindfulness has been linked to improvements in attentional control and emotional regulation across both clinical and non-clinical populations. Although a substantial body of research has examined cognitive and affective outcomes separately, fewer studies have investigated their concurrent within-person changes in educational psychology contexts. In particular, pre-service...
Hongmeng Zhao, Jiaran Lang, Guodong Yang et al.
preprint
Abstract Purpose Traditional offline Mindfulness-Based Stress Reduction (MBSR) is poorly accessible for improving perioperative psychological distress in early-stage breast cancer patients, and the efficacy and sustained effect of online MBSR for this population remain unclear. This study aimed to evaluate the effects of an 8-week online MBSR intervention on psychological distress in patients...
Théo Mouhoud, Timothée Lacombe, Olivier Taieb
preprint
Abstract Background Nutmeg ( Myristica fragrans ) active compounds partially metabolize into amphetamine derivatives with hallucinogenic properties. Acute nutmeg intoxication can induce psychotic states, yet this psychotomimetic potential remains largely unrecognized in clinical practice. We report the first case of nutmeg-induced acute psychosis in an adolescent, highlighting the diagnostic...
Richard Clark Kaufman
preprint
Background: A person with depression, unresolved trauma, a substance problem, and cognitive complaints is treated differently depending on which practitioner they consult. A psychiatrist draws on the monoaminergic and glutamatergic literature. A licensed facilitator draws on the session literature. A naturopath draws on the botanical and nutritional literature. Each draws on a defensible...
Carlo Sala, Jessica Pagano, Eleonora Mangano et al.
preprint
Abstract Major depressive disorder (MDD) is a leading cause of global disability, and a substantial proportion of patients develop treatment-resistant depression (TRD), highlighting the urgent need for mechanistically novel and fast-acting antidepressants. Ketamine has emerged as a paradigm-shifting therapy due to its rapid and robust antidepressant effects, yet its molecular mechanisms in...
Michael Sarvi, Aryan Sarparast
preprint
Abstract Background State-regulated psilocybin services have expanded access outside research settings. Patients seeking these services may have medical and psychiatric complexity not represented in clinical trials, while guidance for clinicians advising them remains limited. We introduce the Psilocybin Education and Assessment Collaborative for Excellence (PEACE), a consultation model within a...