Effect of online mindfulness-based stress reduction therapy on psychological distress of perioperative 0-II breast cancer patients
Hongmeng Zhao, Jiaran Lang, Guodong Yang, Yue Feng, Yaxin Chen, Pudi Liu, Qingyan Li, Huipeng Ren
preprint DOI: 10.21203/rs.3.rs-9913391/v1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial |
|---|---|
| Sample size | 70 |
| Population | Perioperative patients with stage 0–II breast cancer |
| Intervention | Routine breast cancer health education |
| Duration | 8-week intervention, follow-up at week 16 |
| Topics | Meditation |
| Key findings | Online MBSR significantly reduced anxiety (P=0.011), sleep disturbances (P=0.013), and fear of cancer recurrence (P=0.002) compared to active control, and enhanced mindfulness (P<0.001) sustained at follow-up. Depression scores were not significantly superior, but MBSR showed advantages across several efficacy indicators. |
Abstract
Abstract Purpose Traditional offline Mindfulness-Based Stress Reduction (MBSR) is poorly accessible for improving perioperative psychological distress in early-stage breast cancer patients, and the efficacy and sustained effect of online MBSR for this population remain unclear. This study aimed to evaluate the effects of an 8-week online MBSR intervention on psychological distress in patients with stage 0–II breast cancer, and to compare its efficacy with routine health education to provide a feasible psychological intervention strategy.
Methods: A total of 102 perioperative patients with stage 0–II breast cancer were screened, and 70 eligible participants were randomly assigned to either the MBSR group (n = 35) or the active control (AC) group (n = 35). The MBSR group received an 8-week online MBSR intervention combined with routine breast cancer health education, whereas the AC group received equivalent-duration health education alone. Clinical assessments were performed at baseline (T 0 ), post-intervention (week 8, T 1 ), and follow-up (week 16, T 2 ).
Results: Compared to the AC group, participants in the MBSR group showed significant reductions in anxiety ( P = 0.011), sleep disturbances ( P = 0.013), and fear of cancer recurrence ( P = 0.002) after the intervention. Although no significant superiority was observed in depression scores compared to the AC group, the MBSR group demonstrated advantages across multiple efficacy indicators, such as percentage change, improvement difference, and clinical response rate. Furthermore, MBSR participants exhibited enhanced mindfulness levels (P < 0.001), which was sustained during follow-up.
Conclusion: Online MBSR is a potentially effective psychological intervention that can alleviate anxiety and depression in patients with stage 0-II breast cancer, reduce psychological distress, and help patients transition more smoothly into the post-treatment survivorship phase. Trial registration number and date ChiCTR2400079439, 03/01/2024.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cites 19
- Using Self-Report Assessment Methods to Explore Facets of Mindfulness Assessment January 27, 2006
- What defines mindfulness-based programs? The warp and the weft Psychological Medicine December 29, 2016
- An empirical study of the mechanisms of mindfulness in a mindfulness‐based stress reduction program Journal of Clinical Psychology March 6, 2009
- Enhanced dehydroepiandrosterone levels are positively correlated with N3 sleep stage in long-term mindfulness meditation practitioners. Sleep Science 2022
- A study on improving cancer-related fatigue and disease-related psychological variables in patients with cervical cancer based on online mindfulness-based stress reduction: a randomized controlled trial. BMC Women's Health September 19, 2024
and 14 more in the library