Frontiers in Human Neuroscience
February 1, 2016
M. Sharaev, V. V. Zavyalova, Vadim Ushakov et al.
The Default Mode Network (DMN) is a brain system that mediates internal modes of cognitive activity, showing higher neural activation when one is at rest. Nowadays, there is a lot of interest in assessing functional interactions between its key regions, but in the majority of studies only association of Blood-oxygen-level dependent (BOLD) activation patterns is measured, so it is impossible to...
Cognitive Processing
February 1, 2016
Andrew A Fingelkurts, Alexander A Fingelkurts, Tarja Kallio-Tamminen
Using theoretical analysis of self-consciousness concept and experimental evidence on the brain default mode network (DMN) that constitutes the neural signature of self-referential processes, we hypothesized that the anterior and posterior subnets comprising the DMN should show differences in their integrity as a function of meditation training. Functional connectivity within DMN and its...
Neuroscience Letters
January 12, 2016
Julia A. Digangi, Armin Tadayyon, D. Fitzgerald et al.
Recent studies show decreased functional connectivity in the default mode network (DMN) in PTSD; however, few have directly examined combat trauma specifically. There is limited understanding of how combat itself may affect the DMN. Some literature suggests that trauma exposure, rather than PTSD, can disrupt the DMN. To further elucidate the effect of trauma and PTSD on the DMN, we investigated...
Frontiers in Human Neuroscience
2016
Rajanikant Panda, Rose D Bharath, Neeraj Upadhyay et al.
Current research suggests that human consciousness is associated with complex, synchronous interactions between multiple cortical networks. In particular, the default mode network (DMN) of the resting brain is thought to be altered by changes in consciousness, including the meditative state. However, it remains unclear how meditation alters the fast and ever-changing dynamics of brain activity...
Journal of Psychopharmacology
2016
Jana Speth, Clemens Speth, Mendel Kaelen et al.
119 citations
This paper reports on the effects of LSD on mental time travel during spontaneous mentation. Twenty healthy volunteers participated in a placebo-controlled crossover study, incorporating intravenous administration of LSD (75 μg) and placebo (saline) prior to functional magnetic resonance imaging (fMRI). Six independent, blind judges analysed mentation reports acquired during structured...
Journal of Cognitive Neuroscience
December 1, 2015
Amanda Elton, Wei Gao
Abstract: The default mode network (DMN) was first recognized as a set of brain regions demonstrating consistently greater activity during rest than during a multitude of tasks. Originally, this network was believed to interfere with goal-directed behavior based on its decreased activity during many such tasks. More recently, however, the role of the DMN during goal-directed behavior was...
The International Journal of Neuropsychopharmacology
September 10, 2015
Ewelina Rzepa, Luke Tudge, Ciara McCabe
The cannabinoid cannabinoid type 1 (CB1) neutral antagonist tetrahydrocannabivarin (THCv) has been suggested as a possible treatment for obesity, but without the depressogenic side-effects of inverse antagonists such as Rimonabant. However, how THCv might affect the resting state functional connectivity of the human brain is as yet unknown. We examined the effects of a single 10mg oral dose of...
Neuroimage
July 26, 2015
Deniz Vatansever, D.K. Menon, Anne E. Manktelow et al.
157 citations
Initially described as task-induced deactivations during goal-directed paradigms of high attentional load, the unresolved functionality of default mode regions has long been assumed to interfere with task performance. However, recent evidence suggests a potential default mode network involvement in fulfilling cognitive demands. We tested this hypothesis in a finger opposition paradigm with task...
PLoS One
June 30, 2015
Mahiko Konishi, Donald George McLaren, Haakon Engen et al.
210 citations
Although many different accounts of the functions of the default mode network (DMN) have been proposed, few can adequately account for the spectrum of different cognitive functions that utilize this network. The current study used functional magnetic resonance imaging (fMRI) to explore the hypothesis that the role of the DMN in higher order cognition is to allow cognition to be shaped by...
Drug and Alcohol Dependence
June 10, 2015
Reagan R Wetherill, Zhuo Fang, Kanchana Jagannathan et al.
Background Resting-state functional connectivity is a noninvasive, neuroimaging method for assessing neural network function. Altered functional connectivity among regions of the default-mode network have been associated with both nicotine and cannabis use; however, less is known about co-occurring cannabis and tobacco use. Methods We used posterior cingulate cortex (PCC) seed-based...