Scientific Reports
November 23, 2020
A. Zagzoog, Kawthar A. Mohamed, H. J. J. Kim et al.
The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), comparatively little is known about the pharmacology of the less-abundant plant-derived (phyto) cannabinoids. The best-studied transducers of cannabinoid-dependent effects are type 1 and type 2 cannabinoid receptors (CB1R, CB2R). Partial agonism of CB1R...
Addiction Biology
November 2020
Daniela Neuhofer, Sade M Spencer, Vivian C Chioma et al.
Glutamatergic plasticity in the nucleus accumbens core (NAcore) is a key neuronal process in appetitive learning and contributes to pathologies such as drug addiction. Understanding how this plasticity factors into cannabis addiction and relapse has been hampered by the lack of a rodent model of cannabis self-administration. We used intravenous self-administration of two constituents of...
Cureus
July 21, 2020
Shweta Patel, Sahar Khan, M Saipavankumar et al.
69 citations
Marijuana is one of the most abused substances in the world. Marijuana is getting legalized around the world. So, it is crucial to understand its effect on our mental health. Its impact on the schizophrenia spectrum needs our special attention. Even though marijuana has been around for a long time, its exact effects are still unknown. Schizophrenia is a chronic illness affecting approximately...
Journal of Cannabis Research
July 17, 2020
Laura Alethia de la Fuente, Federico Zamberlán, Andrés Sánchez Ferrán et al.
30 citations
BACKGROUND: Widespread commercialization of cannabis has led to the introduction of brand names based on users' subjective experience of psychological effects and flavors, but this process has occurred in the absence of agreed standards. The objective of this work was to leverage information extracted from large databases to evaluate the consistency and validity of these subjective reports, and...
Journal of Clinical Investigation
June 22, 2020
Y. Hurd
The past decade has seen a reduction in society’s perception of cannabis being of any risk or harm. However, we are in a transformational time in which cannabis’ health implications related to neurodevelopment, particularly for vulnerable populations, must challenge such perceptions of harmlessness. The combination of multiple interrelated factors — societal, political, and business — have...
Current Treatment Options in Psychiatry
April 18, 2020
Adina S. Fischer, S. Tapert, Dexter Lee Louie et al.
Purpose of review This review summarizes (1) recent trends in delta-9-tetrahydrocannabionol [THC] and cannabidiol (CBD) content in cannabis products, (2) mechanism of action of THC and CBD and the neurobiological correlates of cannabis use on the developing adolescent brain, (3) effects of cannabis on psychiatric symptoms and daily functioning in youth (i.e., academic performance, cognition,...
Kosmos
April 11, 2020
Alicja Anna Binkowska, Aneta Brzezicka
1 citation
Marihuana jest obecnie jedną z najpopularniejszych i najczęściej zażywanych substancji psychoaktywnych na świecie. Konopie indyjskie, z których produkuje się marihuanę, zawierają ponad 140 różnych związków aktywnych ? kannabinoidów. Najbardziej znane kanabinoidy to tetrahydrokannabinol (THC) i kannabidiol (CBD). Kannabinoidy działają na układ endokannabinoidowy odgrywający istotną rolę w...
Adicciones
February 6, 2020
Cecilia María Díaz-Soto, Guillermo Alonso Castaño Pérez, David Antonio Pineda-Salazar
7 citations
The lack of consensus on the issue of whether the consumption of cannabis favors neurocognition among schizophrenia-diagnosed patients or not, plus methodological problems found in available evidence and the limitations of studies focused on diagnosis and treatment for positive symptoms are sufficient reason for designing new research proposals based on recent brain connectivity models. The...
BMC Psychiatry
January 16, 2020
Jerome Sarris, Justin Sinclair, Diana Karamacoska et al.
247 citations
BACKGROUND: Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory changes. Medicinal cannabis has been reported to have potential efficacy in reducing pain, muscle spasticity, chemotherapy-induced nausea and vomiting, and intractable childhood epilepsy. Yet its potential application in the field of psychiatry is lesser known. METHODS:...
Journal of dual diagnosis
January 2, 2020
Lucia Sideli, Harriet Quigley, Caterina la Cascia et al.
Abstract Objective: This review discusses the relationship between cannabis use and psychotic, bipolar, depressive, and anxiety disorders, as well as suicide. It summarizes epidemiological evidence from cross-sectional and long-term prospective studies and considers possible etiological mechanisms. Methods: Systematic reviews and methodologically robust studies in the field (from inception to...