American Journal of Plant Sciences
2020
Mohamed Ben Amar
3 citations
Abundant literature suggests the hypothesis that cannabis use leads to the onset of psychotic symptoms. However, the nature of the association and the causal link remain controversial. This review aims to identify the risk factors involved in the etiopathogenesis of psychosis or psychotic features. Our electronic search found 1653 studies published until March 1st 2020. Longitudinal studies and...
The Lancet Psychiatry
October 28, 2019
N. Black, E. Stockings, G. Campbell et al.
Background: Medicinal cannabinoids, including medicinal cannabis, pharmaceutical cannabinoids and their synthetic derivatives, including tetrahydrocannabinol (THC) and or cannabidiol (CBD), have been suggested to have a therapeutic role for certain mental health conditions. The primary objective was to review the evidence for cannabinoids in treating symptoms of depression, anxiety,...
British Journal of Pharmacology
May 2019
Alyssa M Myers, Patrick B Siegele, Jeffrey D Foss et al.
It has been suggested that the non-euphorogenic phytocannabinoid cannabidiol (CBD) can ameliorate adverse effects of Δ9 -tetrahydrocannabinol (THC). We determined whether CBD ameliorates cognitive deficits and withdrawal signs induced by cannabinoid CB1 /CB2 receptor agonists or produces these pharmacological effects on its own. The effects of THC or the CB1 /CB2 receptor full agonist WIN55212...
MOJ Addiction Medicine & Therapy
March 21, 2019
N. Vallejo
Cannabis Sativa is the most consumed drug in the world next to alcohol. This article describes its effects, especially that of D9-THC. The perception of the risk of smoking Cannabis has followed a downward curve in the last 15years Granting it to connotation of "recreational" and ignoring or ignoring its risks for psychophysical health. In some countries of the Northern Hemisphere it is usually...
2019
17 citations
Researchers, program administrators, and practicing clinicians explain the most recent developments in using psychedelic substances to treat psychological, physiological, and social problems. More than a decade ago, the U.S. government lifted its ban on all testing of psychedelic substances. Winkelman and Sessa now provide updated scientific research and applications of these substances, now...
Talanta
September 6, 2018
Céline Burnier, Pierre Esseiva, Christophe Roussel
Nowadays, Gas Chromatography Mass Spectrometry (GC-MS) is mainly used in forensic sciences but suffers from limitations when the analysed compounds are thermally instable as it is the case for THC-A (Tetrahydrocannabinolic Acid) which is converted into Δ9-THC (Δ9-Tetrahydrocannabinol) that subsequently partially degrades. We propose herein a Fast High Pressure Liquid Chromatography...
Psychological Medicine
September 4, 2018
Helen Valerie Curran, Chandni Hindocha, Celia J. A. Morgan et al.
65 citations
BACKGROUND: Changes in cannabis regulation globally make it increasingly important to determine what predicts an individual's risk of experiencing adverse drug effects. Relevant studies have used diverse self-report measures of cannabis use, and few include multiple biological measures. Here we aimed to determine which biological and self-report measures of cannabis use predict cannabis...
Journal of Affective Disorders
August 1, 2018
Carrie Cuttler, Alexander Spradlin, Ryan J Mclaughlin
Cannabis is commonly used to alleviate symptoms of negative affect. However, a paucity of research has examined the acute effects of cannabis on negative affect in everyday life. The current study provides a naturalistic account of perceived changes in symptoms of depression, anxiety, and stress as a function of dose and concentration of Δ9tetrahydrocannabinol (THC) and cannabidiol (CBD). Data...
Journal of Food and Drug Analysis
July 3, 2018
V. Cardenia, Tullia Gallina Toschi, Simona Scappini et al.
A routine method for determining cannabinoids in Cannabis sativa L. inflorescence, based on Fast gas chromatography coupled to mass spectrometry (Fast GC/MS), was developed and validated. To avoid the decarboxylation of carboxyl group of cannabinoids, different derivatization approaches, i.e. silylation and esterification (diazomethane-mediated), reagents and solvents (pyridine or ethyl...
Medical Cannabis and Cannabinoids
June 12, 2018
Jürg Gertsch
The botanical drug cannabis flos (inflorescence of Cannabis sativa L.) has a unique popular status as being a potent recreational drug and bona fide universal remedy (panacea). Generally, cannabinoids exert therapeutic effects in a broad range of pathophysiologies related to inflammation, pain, metabolic and stress-related conditions in preclinical animal models. However, the translation of...