Psychopharmacology
May 1, 2019
Thomas R. Arkell, Nicholas Lintzeris, Richard C. Kevin et al.
177 citations
BACKGROUND: The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differentially affect driving and cognition relative to THC-dominant cannabis. AIMS:...
Addiction Biology
May 1, 2019
Shaul Schreiber, Miaad Bader, Tatiana Lenchinski et al.
30 citations
Synthetic cannabinoids are psychoactive substances designed to mimic the euphorigenic effects of the natural cannabis. Novel unregulated compounds appear once older compounds become illegal. It has been previously reported that synthetic cannabinoids are different than Δ9 -tetrahydrocannabinol (Δ9 -THC) as they have chemical structures unrelated to Δ9 -THC, different metabolism and, often,...
Journal of Psychopharmacology
April 23, 2019
Matthew B. Wall, Rebecca Pope, Tom P. Freeman et al.
89 citations
BACKGROUND: -tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC. AIMS: We examined the effects of two strains of cannabis and placebo on the human brain's resting-state networks using fMRI. METHODS: Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug...
Psychopharmacology
April 9, 2019
Vincent T Mensen, Annabel Vreeker, Johan Nordgren et al.
Background: Synthetic cannabinoids (SCs) are a class of new psychoactive substances that have been rapidly evolving around the world throughout recent years. Many different synthetic cannabinoid analogues are on the consumer market and sold under misleading names, like "spice" or "incense." A limited number of studies have reported serious health effects associated with SC use. In this study,...
Alcoholism & Drug Abuse Weekly
April 8, 2019
Alison Knopf
Daily use of marijuana (cannabis) is associated with a greater than three times increased risk of psychotic disorder compared to never users, according to a study published in Lancet Psychiatry. This risk increased to nearly five times if high‐potency cannabis was used. Across the 11 sites included in the study, if high‐potency cannabis were not available, 12.2 percent of cases of first‐episode...
Molecular Psychiatry
April 2019
Michael L Miller, Benjamin J. Chadwick, Dara L Dickstein et al.
Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes significant maturation during adolescence, a period when cannabis use in humans has been linked to subsequent vulnerability to psychiatric disorders such as addiction and schizophrenia. Here, we investigated in a rat...
Revista médica de Chile
April 1, 2019
Manuel E. Cortés, Yanara A Bernal, Renán Orellana
4 citations
Señor Editor:La legalización del uso medicinal y recreativo de la marihuana (Cannabis sativa) es un tema de controversia mundial.Un artículo en Nature Reviews Neuroscience 1 destaca que el uso de Cannabis es cada vez más importante para la medicina moderna, especialmente en el tratamiento del dolor y de trastornos motores.Sin embargo, su uso más extendido es «recreacional» debido a las...
Adicciones
April 1, 2019
Leticia García-Álvarez, Jesús J. Gomar, María Paz García‐portilla et al.
16 citations
Editorial of vol. 31, n. 2.
The Brown University Child and Adolescent Behavior Letter
April 1, 2019
Alison Knopf
Lasting effects of adolescent cannabis use are even more pronounced than those for alcohol, researchers suggest in a new study of the role of impaired cognition on substance use.
MOJ Addiction Medicine & Therapy
March 21, 2019
N. Vallejo
Cannabis Sativa is the most consumed drug in the world next to alcohol. This article describes its effects, especially that of D9-THC. The perception of the risk of smoking Cannabis has followed a downward curve in the last 15years Granting it to connotation of "recreational" and ignoring or ignoring its risks for psychophysical health. In some countries of the Northern Hemisphere it is usually...