Richard C. Kevin

Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome.

NEJM evidence September 2023 Philip E Mosley, Lachlan Webb, Anastasia Suraev et al.

BACKGROUND: Tourette syndrome is characterized by chronic motor and vocal tics. There is preliminary evidence of benefit from cannabis products containing Δ9-tetrahydrocannabinol (THC) and that coadministration of cannabidiol (CBD) improves the side-effect profile and safety. METHODS: In this double-blind, crossover trial, participants with severe Tourette syndrome were randomly assigned to a...

DOI: 10.1056/evidoa2300012 (opens in new tab) Full text (opens in new tab)

Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis

Psychopharmacology October 13, 2022 Nadia R. P. W. Hutten, Thomas R. Arkell, Frederick Vinckenbosch et al. 36 citations

RATIONALE: Delta-9-tetrahydrocannabinol (THC), an active component of cannabis, can cause anxiety in some users during intoxication. Cannabidiol (CBD), another constituent of cannabis, has anxiolytic properties suggesting that cannabis products containing CBD in addition to THC may produce less anxiety than THC-only products. Findings to date around this issue have been inconclusive and could...

DOI: 10.1007/s00213-022-06248-9 (opens in new tab) Full text (opens in new tab) Cannabidiol Anxiety Cannabis Tetrahydrocannabinol +4

Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials

Addiction Biology December 22, 2021 Thomas R. Arkell, Richard C. Kevin, Frederick Vinckenbosch et al. 45 citations

Some evidence suggests that males and females may differ in their responses to acute cannabis effects, including subjective drug effects and behavioural effects, and cannabinoid pharmacokinetics. This is significant given current changes to cannabis-related policies and, in consequence, increased cannabis accessibility. The present study combines data from two randomized controlled trials to...

DOI: 10.1111/adb.13125 (opens in new tab) Cannabidiol Randomized controlled trial Effects of cannabis Cannabis dependence +1

Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition

Psychopharmacology May 1, 2019 Thomas R. Arkell, Nicholas Lintzeris, Richard C. Kevin et al. 177 citations

BACKGROUND: The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differentially affect driving and cognition relative to THC-dominant cannabis. AIMS:...

DOI: 10.1007/s00213-019-05246-8 (opens in new tab) Full text (opens in new tab) Cannabidiol Tetrahydrocannabinol Crossover study Effects of cannabis +4

Acute and residual effects in adolescent rats resulting from exposure to the novel synthetic cannabinoids AB-PINACA and AB-FUBINACA.

Journal of Psychopharmacology June 2017 Richard C. Kevin, Katie E Wood, Jordyn Stuart et al.

Synthetic cannabinoids (SCs) have rapidly proliferated as recreational drugs, and may present a substantial health risk to vulnerable populations. However, information on possible effects of long-term use is sparse. This study compared acute and residual effects of the popular indazole carboxamide SC compounds AB-PINACA and AB-FUBINACA in adolescent rats with ∆9-tetrahydrocannabinol (THC) and...

DOI: 10.1177/0269881116684336 (opens in new tab) Full text (opens in new tab) Ab-fubinaca Ab-pinaca Cannabinoid Adolescent +2