In this study, a reaction pathway for converting the psychoactive compound Δ9-THC into the nonpsychoactive cannabidiol (CBD) was proposed. Related cannabinoids, including Δ8-THC and cannabinol (CBN), were also examined. The transformation proceeds via two key steps: (i) hydrogen elimination and cyclic ether ring cleavage, and (ii) hydrolysis to form hydroxyl groups, facilitated by boron...
Revista Brasileira de CannabisJuly 22, 2026Cláudio Yuri Rodrigues da Silva, Evelyn Abreu De Amorim, Lucas Gonçalves Vilas et al.
A Ecopsicologia é uma abordagem integradora que busca conectar a sustentabilidade à saúde mental e emocional com a reconexão do ser humano à natureza. Ela parte da premissa de que o bem-estar humano está intrinsecamente ligado ao equilíbrio ambiental, estimulando práticas que promovam a sustentabilidade e o contato direto com a natureza. Plantar sua própria cannabis para fins terapêuticos se...
Cannabis is one of the most widely used psychoactive substances, with higher use rates in countries that have implemented policies to legalize medical or recreational use. Following the development of cannabis products with concentrations well above 10% THC (high potency, delta-9 tetrahydrocannabinol), the number of psychosis cases has also increased. Cannabis-attributable psychosis cases...
Posttraumatic stress disorder (PTSD) is characterized by difficulties in emotion regulation and altered recruitment of prefrontal control systems during cognitive reappraisal. Cannabinoid signaling has been implicated in stress and affect regulation, yet dose-dependent effects of acute delta-9-tetrahydrocannabinol (THC) on the neural mechanisms supporting reappraisal in PTSD remain unclear. In...
Since the discovery of the first antipsychotic, pharmacological treatment of schizophrenia (SCZ) has primarily relied on dopamine D2 receptor antagonist. However, variability in treatment responses highlights the need for novel biomarkers and therapeutics targets. Here, we developed a dual-hit mouse model combining maternal immune activation (MIA) induced by polyinosinic-polycytidylic acid...
CannabisJuly 15, 2026Saara Greene, Allyson Ion, Rochelle Maurice et al.
Objective: This paper presents rich and in-depth insights emerging from "Wading through the Weeds" (WttW), a participatory arts-based research study that used the Photovoice method to centre the lived experience of 23 mothers throughout Canada who consumed cannabis during pregnancy, lactation and motherhood. Method: Specifically, this paper examines and elucidates the ways that the mothers in...
Background: Cannabis use among adolescents with depression is prevalent. Dysfunction of the reward system has been implicated in each condition separately, yet rarely examined together. Here, we investigated resting-state properties of reward networks in an adolescent sample with diverse internalizing psychopathology and cannabis use patterns. Methods: Clinicians interviewed adolescents and...
Biological PsychologyJuly 9, 2026Nattanon Bunrodchu, Ekkasit Kumarnsit, Wan Khairunizam Wan Ahmad et al.
Long-term cannabis use can result in the development of cannabis use disorder (CUD) and dependence via the endocannabinoid system pathway. A brain network that has been consistently linked to various stages of addiction and various substances is the default mode network (DMN). By comparing EEG features between cannabis users and healthy participants, this study sought to identify EEG-based...
BACKGROUND Cannabis-induced psychosis presents complex sex-based disparities that challenge traditional epidemiological patterns. While males demonstrate higher cannabis use rates, emerging evidence reveals paradoxical vulnerability patterns where females may show heightened susceptibility to cannabis-related psychotic outcomes despite lower consumption rates. OBJECTIVE To map evidence for...
BACKGROUND AND AIMS Although many people who use cannabis report mood-enhancing effects, affective responses are thought to vary within and between individuals. This study examined the bidirectional associations between momentary affect and cannabis use and the potential moderating role of emotion regulation in this. DESIGN Intensive longitudinal observational study using experience sampling...