Psychopharmacology
May 2022
Andrew Fares, Christine M Wickens, Robert E Mann et al.
With alcohol and cannabis remaining the most commonly detected drugs in seriously and fatally injured drivers, there is a need to understand their combined effects on driving. The present study examined the effects of combinations of smoked cannabis (12.5% THC) and alcohol (target BrAC 0.08%) on simulated driving performance, subjective drug effects, cardiovascular measures, and self-reported...
Addiction Biology
May 2022
James R Coleman, Dan Madularu, Richard J. Ortiz et al.
Social norms and legality surrounding the use of medical and recreational cannabis are changing rapidly. The prevalence of cannabis use in adolescence is increasing. The aim of this study was to assess any sex-based neurobiological effects of chronically inhaled, vaporised cannabis on adolescent female and male mice. Female and male mice were exposed daily to vaporised cannabis (10.3%...
Psychopharmacology
May 2022
Hannah Thomson, Izelle Labuschagne, Lisa-Marie Greenwood et al.
Regular cannabis use has been associated with brain functional alterations within frontal, temporal, and striatal pathways assessed during various cognitive tasks. Whether such alterations are consistently reported in the absence of overt task performance needs to be elucidated to uncover the core neurobiological mechanisms of regular cannabis use. We aim to systematically review findings from...
Psychopharmacology
May 2022
Anahita Bassir Nia, Maria J Orejarena, Leigh Flynn et al.
Cannabis is the most common illicit drug used in the USA and its use has been rising over the past decade, while the historical gap in rates of use between men and women has been decreasing. Sex differences in the effects of cannabinoids have been reported in animal models, but human studies are sparse and inconsistent. We investigated the sex differences in the acute subjective,...
Psychopharmacology
May 2022
Ashley M Francis, Andrea Parks, Joëlle Choueiry et al.
Long-term cannabis use has been associated with the appearance of psychotic symptoms and schizophrenia-like cognitive impairments; however these studies may be confounded by concomitant use of tobacco by cannabis users. We aimed to determine if previously observed cannabis-associated deficits in sensory gating would be seen in cannabis users with no history of tobacco use, as evidenced by...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
May 1, 2022
Christine M Wickens, Madison Wright, Robert E Mann et al.
Co-use of alcohol and cannabis is associated with increased frequency and intensity of use and related problems. This study examined acute effects of alcohol and cannabis on mood, subjective experience, cognition, and psychomotor performance. Twenty-eight healthy cannabis users aged 19-29 years with recent history of binge drinking completed this within-subjects, double-blind, double-dummy,...
Pharmacological Research
May 1, 2022
C. Carvalho, M. Vieira-Coelho
OBJECTIVE Cannabis sativa is a recreational drug commonly consumed in Europe and is getting popularity for both recreational and therapeutic use. In some individuals, the use of cannabis leads to psychotic disorders. This systematic review summarizes the current evidence linking genetic polymorphisms and inter-individual susceptibility to psychosis induced by cannabis. METHOD Studies published...
Psychopharmacology
May 1, 2022
Sam Craft, Jason Ferris, Monica J Barratt et al.
19 citations
Synthetic cannabinoid receptor agonists (SCRAs) may be used as an alternative to natural cannabis; however, they may carry a greater risk of problematic use and withdrawal. This study aimed to characterise the withdrawal symptom profile of SCRAs and compare their profile of effect with high-potency herbal cannabis. Global Drug Survey data (2015 and 2016) were used to access a clinically...
Psychopharmacology
April 29, 2022
Will Lawn, Natalia Fernandez‐Vinson, Claire Mokrysz et al.
25 citations
BACKGROUND: Preclinical and human studies suggest that adolescent cannabis use may be associated with worse cognitive outcomes than adult cannabis use. We investigated the associations between chronic cannabis use and cognitive function in adolescent and adult cannabis users and controls. We hypothesised user-status would be negatively associated with cognitive function and this relationship...
Annual Review of Law and Social Science
April 28, 2022
Robert A. Mikos
4 citations
Interest in psychedelics is booming, heralding a possible psychedelic renaissance in the United States. But policy makers interested in expanding access to psychedelic substances would be wise to heed lessons gleaned from the past 25 years of marijuana law reforms. That experience suggests that it may prove impossible to repeal or narrow the federal ban on psychedelics in the near term, but...