Biological Psychiatry
July 15, 2022
Randall J Ellis, Anissa Bara, Claudia A Vargas et al.
Cannabis remains one of the most widely abused drugs during pregnancy. In utero exposure to its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), can result in long-term neuropsychiatric risk for the progeny. This study investigated epigenetic signatures underlying these enduring consequences. Rat dams were exposed daily to THC (0.15 mg/kg) during pregnancy, and adult male...
Cannabis
July 11, 2022
Brianna R. Altman, Mitch Earleywine, Maha N. Mian et al.
Links between cannabis use and psychosis generate research and media attention. Cannabis users have outscored non-users on the Schizotypal Personality Questionnaire-Brief (SPQ-B) in multiple studies, but previous work suggests that groups do not differ if biased items are removed. The present study examined links between schizotypal personality and cannabis use in a large sample recruited from...
Cannabis
July 11, 2022
Mitch Earleywine, Maha N. Mian, Brianna R. Altman et al.
11 citations
Psychedelic-assisted psychotherapy has established antidepressant effects. Cannabis users appear to expect high doses administered in a session much like psychedelic-assisted psychotherapy to create comparable subjective effects. The current studies explored expectations of antidepressant effects of such cannabis-assisted sessions to replicate and extend previous work. Users not only expected a...
Neuropsychopharmacology
July 2022
Andrew J Kesner, Yolanda Mateo, Karina P Abrahao et al.
Withdrawal symptoms are observed upon cessation of cannabis use in humans. Although animal studies have examined withdrawal symptoms following exposure to delta-9-tetrahydrocannabinol (THC), difficulties in obtaining objective measures of spontaneous withdrawal using paradigms that mimic cessation of use in humans have slowed research. The neuromodulator dopamine (DA) is affected by chronic THC...
Brain Sciences
June 23, 2022
Thorsten Rudroff, Craig D. Workman, Phillip E. Gander et al.
3 citations
Δ9-Tetrahydrocannabinol is the main psychoactive component of cannabis and cannabidiol is purportedly responsible for many of the medicinal benefits. The effects of Δ9-tetrahydrocannabinol and cannabidiol in younger populations have been well studied; however, motor function, cognitive function, and cerebral glucose metabolism in older adults have not been extensively researched. The purpose of...
JAMA Health Forum
June 17, 2022
Kevin F. Boehnke, Alan K. Davis, Jenna McAfee
20 citations
In 2020, Oregon became the first state in the US to decriminalize use of many illicit substances, including mushrooms containing psilocybin, and allow adults aged 21 years and older to take psilocybin under supervision in state-licensed service centers.Numerous states and municipalities have since proposed similar policies, 1 a process catalyzed by excitement about positive clinical trials of...
June 8, 2022
Szczypka Glen, Jessica K. Pepper, Annice Kim
Delta-8 tetrahydrocannabinol (THC) is a newly popular cannabinoid that can be purchased easily at gas stations, vape shops, and online retailers in most regions of the United States. The US Food and Drug Administration (FDA) has expressed the need for novel data sources to understand the use of products like Delta-8 and rapidly detect potential safety issues. Using social media platform Reddit,...
European Psychiatry
June 1, 2022
M. Gonçalves, J. Romão, R. André et al.
Introduction Neurocognitive deficits amongst patients with schizophrenia are considered one of schizophrenia’s central features. These deficits appear to be present from the first episode of psychosis (FEP) and certain cognitive impairments could be components of a genetic vulnerability to schizophrenia. Regarding research on cannabis and cognition in schizophrenia, different studies have...
European Psychiatry
June 1, 2022
Fabiana Corsi-Zuelli, C. Loureiro, Rosana Shuhama et al.
Introduction We have previously shown that the association between frequent cannabis use and psychosis is more likely in subgroups with low-grade inflammation than subgroups without (PMID: 33736715). The role of immune-related polymorphisms remains unknown. Objectives To explore whether polymorphisms affecting the function of key immune regulatory proteins moderate the association between...
BJPsych Open
June 1, 2022
Rafael Gafoor
Aims There is strong evidence from systematic reviews and meta-analyses that cannabis use is related to an elevated risk of developing a subsequent psychotic illness. It is less clear if the length of cannabis abstinence is related to the risk of developing a psychotic episode. We explore the relationship between length of cannabis abstinence and subsequent risk of a psychotic episode. Methods...