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Presse medicale (Paris, France : 1983) October 23, 2004 Xavier Aknine
The use of ecstasy (MDMA) has developed in the young since the eighties, particularly in festive settings. Among the severe adverse events induced by this synthetic drug, the hepatotoxicity related to MDMA and to its physiopathological mechanism warrant attention. A 21 year-old man consulted for anaemia that had persisted over the past months with abnormality in hepatic profile. The...
Drug and Alcohol Dependence October 5, 2004 G K L Butler, A M J Montgomery
The present study investigated characteristics of recreational drug users, especially 'ecstasy' (MDMA) users, in 254 undergraduates. All participants completed a drug history questionnaire (DHQ), the impulsiveness venturesomeness and empathy questionnaire, a novel risk-taking task (Bets16), and 59 also completed the tri-dimensional personality questionnaire (TPQ). DHQ responses allocated...
Anthropology of Consciousness September 1, 2004 Grant J. Rich
This is an interview with author Lester Grinspoon, M.D., whose work on psychoactive substances over the last thirty‐five years has been highly influential. His book, Marihuana: The Forbidden Medicine (written with James B. Bakalar), is a classic source on the medical marijuana controversy. His books Psychedelic Drugs Reconsidered and Cocaine: A Drug and Its Social Evolution are standards in the...
European Journal of Neuroscience July 15, 2004 Patricia Robledo, Victoria Mendizábal, Jordi Ortuño et al. 40 citations
Abstract The involvement of µ‐opioid receptors in the rewarding properties of MDMA was explored in µ‐opioid receptor knockout mice using the conditioning place preference paradigm. The associated release of dopamine in the nucleus accumbens was investigated by in vivo microdialysis. A significant rewarding effect of MDMA (10 mg/kg, i.p.) was observed in both wild‐type and µ‐opioid receptor...
Drogues santé et société July 7, 2004 Stéphane Potvin, Emmanuel Stip, Jean-Yves Roy 6 citations
Dans le débat sur la décriminalisation du cannabis, ce sont les conséquences de la consommation de cette substance psychoactive qui interpellent les experts. Rarement s’interroge-t-on, toutefois, sur la nature de l’intoxication au cannabis. Or, un survol attentif de la littérature laisse entrevoir de multiples rapports entre les effets du cannabis et la phénoménologie de la schizophrénie....
CRC Press eBooks June 25, 2004 1 citation
The association between cannabis and psychosis is not a new one. It was described as far back as 1845 that use of hashish was associated with acute psychotic reactions that sometimes could last up to days.1 Since then several other studies support an association between cannabis and psychosis (reviewed in reference 2). However, the precise nature of the association remains unclear. The existing...
Nature Neuroscience June 2004 Susana Mato, Vivien Chevaleyre, David Robbe et al.
Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated...
Addictive Behaviors June 2004 Andrew Scholey, Andrew C. Parrott, Tom Buchanan et al.
Recreational Ecstasy/MDMA (3,4-methylenedioxymethamphetamine) users often take a variety of psychoactive drugs, but there is little empirical data on how these drug consumption patterns change with greater experience of Ecstasy. The aim of this study was to compare the polydrug usage patterns reported by non-Ecstasy users, novice Ecstasy users, moderate Ecstasy users, and heavy Ecstasy users....
Cambridge University Press eBooks May 27, 2004 Deepak Cyril D’souza, Hyun Sang Cho, Edward Belk Perry et al. 32 citations
Hypotheses relating to the association between cannabis and psychosis may be divided into two groups. The exogenous hypothesis, which has received far greater attention, suggests that the consumption of cannabinoid compounds produces psychotic disorders by mechanisms that are extrinsic to the pathophysiology of naturally occurring psychoses. As discussed elsewhere in this book, converging...
Human Psychopharmacology: Clinical and Experimental May 5, 2004 Michelle Wareing, John E. Fisk, Philip N. Murphy et al. 76 citations
Abstract Previous research suggests that MDMA users are impaired in various aspects of cognitive functioning, however, it remains unclear whether they might experience deficits in established measures of verbal working memory functioning. In the present study current and previous MDMA users were compared with non‐users on verbal working memory measures including reading and computation span....