Journal of Psychoactive Drugs
2024
Karim Ait Bentaleb, Mélanie Boisvert, Valérie Tourjman et al.
Ketamine administration leads to a psychotomimetic state when taken in large bolus doses, making it a valid model of psychosis. Therefore, understanding ketamine's effects on brain functioning is particularly relevant. This meta-analysis focused on neuroimaging studies that examined ketamine-induced brain activation at rest and during a task. Included are 10 resting-state studies and 23...
Schizophrenia Bulletin Open
2023
Julien Ouellet, Sean Spinney, Roxane Assaf et al.
Abstract Objectives Increasing evidence implicates cannabis consumption as a key risk factor in the development of psychosis, but the mechanisms underpinning this relationship remain understudied. This study proposes to determine whether sleep disruption acts as a mediator of the cannabis-to-psychosis relationship. Study Design This longitudinal study assessed measures of cannabis use...
Addiction
January 19, 2022
Laura Dellazizzo, Stéphane Potvin, S. Giguère et al.
BACKGROUND Cannabis is among the most consumed psychoactive substances world-wide. Considering changing policy trends regarding the substance, it is crucial to understand more clearly its potential acute and residual adverse effects from a public health viewpoint. Cognitive function is one of the targeted areas with conflicting findings. This meta-review measured the magnitude of acute and...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
August 10, 2020
Simon Zhornitsky, Julie Pelletier, Roxane Assaf et al.
BACKGROUND Impairment in cognition is frequently associated with acute cannabis consumption. However, some questions remain unanswered as to which deficits are most prominent and which demographic groups are most vulnerable. METHODS A literature search yielded 40 experimental studies of acute administration of partial CB1 receptor agonists (i.e. cannabis, THC, and nabilone) that assessed...
Pharmaceuticals
May 21, 2012
Simon Zhornitsky, Stéphane Potvin
Cannabidiol (CBD), a major phytocannabinoid constituent of cannabis, is attracting growing attention in medicine for its anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, up to this point, a comprehensive literature review of the effects of CBD in humans is lacking. The aim of the present systematic review is to examine the randomized and crossover studies that...
Journal of Psychoactive Drugs
June 1, 2007
Mohamed Ben Amar, Stéphane Potvin
Growing evidence supports the hypothesis that cannabis consumption is a risk factor for the development of psychotic symptoms. Nonetheless, controversy remains about the causal nature of the association. This review takes the debate further through a critical appraisal of the evidence. An electronic search was performed, allowing to identify 622 studies published until June 1st 2005....
Drogues santé et société
July 7, 2004
Stéphane Potvin, Emmanuel Stip, Jean-Yves Roy
6 citations
Dans le débat sur la décriminalisation du cannabis, ce sont les conséquences de la consommation de cette substance psychoactive qui interpellent les experts. Rarement s’interroge-t-on, toutefois, sur la nature de l’intoxication au cannabis. Or, un survol attentif de la littérature laisse entrevoir de multiples rapports entre les effets du cannabis et la phénoménologie de la schizophrénie....