The International Journal of Neuropsychopharmacology
June 2011
Aurelie A Boucher, Glenn E. Hunt, Jacques Micheau et al.
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of Δ9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We...
Experimental Neurology
June 2011
Laxmikant S Deshpande, Robert E Blair, Robert J DeLorenzo
Developing cannabinoid-based medication along with marijuana's recreational use makes it important to investigate molecular adaptations the endocannabinoid system undergoes following prolonged use and withdrawal. Repeated cannabinoid administration results in development of tolerance and produces withdrawal symptoms that may include seizures. Here we employed electrophysiological and...
Psychopharmacology
June 2011
Florentia Hadjiefthyvoulou, John E. Fisk, Catharine Montgomery et al.
Prospective memory (PM) deficits in recreational drug users have been documented in recent years. However, the assessment of PM has largely been restricted to self-reported measures that fail to capture the distinction between event-based and time-based PM. The aim of the present study is to address this limitation. Extending our previous research, we augmented the range laboratory measures of...
Human Psychopharmacology Clinical and Experimental
June 1, 2011
John E. Fisk, Catharine Montgomery, Florentia Hadjiefthyvoulou
13 citations
OBJECTIVE: Previous research suggests that ecstasy users are impaired in processing visuospatial information. However, for the most part, the deficits observed appear to involve the recall and recognition of complex visual and geometric patterns. The present research sought to determine whether ecstasy use was associated with deficits in serial spatial recall and visuospatial working memory...
Emergency Medicine Journal
June 1, 2011
Miguel Galicia, Santiago Nogué, Òscar Miró
To describe the epidemiological profile and clinical manifestations of liquid ecstasy (GHB) poisonings. All cases of GHB poisoning or overdose admitted to the Emergency Department (ED) of the Hospital Clinic (Barcelona) between 2000 and 2007 were recorded. A total of 505 patients (mean age 24.7 years, 68% men) were included. Most patients were brought to the hospital by ambulance (98%), during...
Neuroscience Letters
May 27, 2011
Andreas M Stadelmann, Georg Juckel, Larissa Arning et al.
Numerous studies demonstrated a close relationship between cannabis abuse and schizophrenia with similar impairments in cognitive processing, particularly in P300 generation. Recently, an (AAT)n triplet repeat polymorphism within the cannabinoid receptor gene CNR1 has been found to be associated with both schizophrenia and substance dependence, and to modulate the P300 potential. As previously...
Psychopharmacology
April 2011
Amanda M George, Tim D Windsor, Bryan Rodgers
Whether the reported poorer mental health of ecstasy users is due to a bias in endorsement of somatic symptoms has been postulated, but rarely examined. The purpose of this study is to investigate whether levels of ecstasy use were associated with differential probabilities of endorsing somatic mental health symptoms. Current ecstasy users aged 24-30 years (n = 316) were identified from a...
Clinical Toxicology
April 1, 2011
Jan Krul, Armand R J Girbes
OBJECTIVE. The objective of this study was to determine the health disturbances and to assess the severity of the incidents as reported during a 9-year experience of gamma-hydroxybutyrate (GHB)-related First Aid Attendees attending First Aid Stations at rave parties. DESIGN. This study was a prospective observational study of self-referred patients from the year 2000 to 2008. During rave...
The Open Addiction Journal
March 29, 2011
Con Stough
3 citations
The aim of this study was to investigate car driving skills and cognitive abilities after the consumption of methamphetamine and MDMA. In previous studies we have demonstrated significant decrements following sedative drugs such as cannabis, and stimulants such as dexamphetamine. We have also documented the presence of stimulant drugs in many fatal traffic accidents, especially those involving...
The Open Addiction Journal
March 29, 2011
Allison J Matthews
1 citation
Remembering to do things in the future (prospective memory) and remembering things in our past (retrospective memory) are important everyday memory skills. Several studies suggest an association between use of ecstasy (3,4-methylenedioxymethamphetamine) and impairments in prospective (remembering to remember) and retrospective memory (recollection of past events) [1, 2]. However, some research...