Since the 1990s, three major (neo)shamanic linages associated with sacred plants use have arrived in Uruguay. Each one comes from a particular Latin American national context: Brazil and its ayahuasca religions, Peru and vegetalismo, Mexico and the Red Path. In what way do these practices and discourses develop in a Latin American country imagined as "white," "without indigenous people," and...
Few commodities are as global as drugs. Cannabis, opium, heroin, amphetamines, lysergic acid diethylamide (LSD), khat, psychedelic cacti and mushrooms as well as an interminable list of other natural or synthesised substances travel and are consumed around the globe for all possible reasons. Human migration, trade, cultural trends, medical practice, political repression: together they...
Harm Reduction JournalJanuary 5, 2018Niamh Day, Joshua Criss, Benjamin J Griffiths et al.
Drug checking is a harm reduction strategy which allows users to check the content and purity of illicit drugs. Although drug checking has been trialled internationally, with demonstrated value as a harm reduction and health promotion strategy, the use of such services in Australia remains a contentious issue. This study aimed to investigate the proportion and patterns of illicit drug use among...
PLoS One2018Qingfang Meng, Beth Buchanan, Jonathan Zuccolo et al.
In the past 50 years, Cannabis sativa (C. sativa) has gone from a substance essentially prohibited worldwide to one that is gaining acceptance both culturally and legally in many countries for medicinal and recreational use. As additional jurisdictions legalize Cannabis products and the variety and complexity of these products surpass the classical dried plant material, appropriate methods for...
Psychoactive cannabinoids from the marijuana plant (phytocannabinoids), from the body (endocannabinoids), and from the research lab (synthetic cannabinoids) produce their discriminative stimulus effects by stimulation of CB1 receptors in the brain. Early discrimination work with phytocannabinoids confirmed that Δ9-tetrahydrocannabinol (Δ9-THC) is the primary psychoactive constituent of the...
Synthetic cannabinoids (spice), which are used frequently worldwide, are more potent than herbal compounds and also have more side effects in comparison. A 23-year-old male was admitted to the emergency unit with altered consciousness. There was no sign of trauma, and his medical history did not reveal any chronic illness. Computed tomography revealed a large frontal hematoma extending to the...
Synthetic cannabinoid receptor agonists (SCRAs) have proliferated as new psychoactive substances (NPS) over the past decade. Relative to other classes of NPS, SCRAs are structurally heterogeneous; however, most SCRAs act as potent, high-efficacy agonists of cannabinoid type 1 and type 2 receptors (CB1 and CB2, respectively). Characterization of the pharmacology and toxicology of these...
Introduction:The limbic system plays an important role in neural mechanisms related to emotion and memory.Hallucinogenic drugs are a factor affecting the functioning of this system and interfering with its nervous system regulation.Recent studies on adolescent users of hallucinogenic drugs, such as marijuana, have shown some degree of behavioral and emotional disorders.Cannabinoids, compounds...
Background: Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate (NMDA) glutamatergic receptor antagonist which has been found to be effective...
Basic self-disturbance (BSD) is proposed to constitute the clinical core of schizophrenia spectrum disorders, including prodromal states and schizotypy. Anomalous self-experiences (ASEs) are suggested as phenotypic variants of BSD, representing markers of schizophrenia vulnerability. However, ASEs are not restricted to the schizophrenia spectrum, but may also occur in non-psychotic states like...