Biomolecules
October 12, 2022
Justin Matheson, Zoe Bourgault, Bernard Le Foll
Cannabidiol (CBD) is a non-intoxicating cannabinoid compound with diverse molecular targets and potential therapeutic effects, including effects relevant to the treatment of psychiatric disorders. In this scoping review, we sought to determine the extent to which sex and gender have been considered as potential moderators of the neuropsychiatric effects and pharmacokinetics of CBD. In this...
Clinical Toxicology
October 1, 2022
A King, S L Hill, M Pucci et al.
Synthetic cannabinoid receptor agonists (SCRA) are commonly encountered new psychoactive substances. Here we report the recent detection of ADB-BUTINACA in samples from patients attending United Kingdom emergency departments with toxicity after suspected drug misuse and describe the associated clinical features. Consenting adults (≥16 y) presenting to participating hospitals with toxicity after...
Anesthesiology
September 12, 2022
Albert Dahan, Erik Olofsen, Thomas K. Henthorn et al.
3 citations
We thank Bowdle et al.1 for their interest in our article,2 and for the important issue they raise, paraphrased as follows: what is the best anthropocentric description of the "mind-altering" effects of a heterogeneous group of compounds and drugs that act at the brain and cause significant changes in mental state. The group of drugs that we are referring to includes N-methyl-d-aspartate (NMDA)...
Addiction Science & Clinical Practice
September 4, 2022
Lukas Andreas Basedow, Melina Felicitas Wiedmann, Veit Roessner et al.
17 citations
Abstract Background Post-traumatic stress disorder (PTSD) and substance use disorders (SUDs) often co-occur in adolescent patients. Previous research has shown that these patients differ from SUD patients without PTSD in terms of their substance use patterns. In this study, we aimed to test whether substance use in this population is related to an attempt to self-medicate PTSD-related symptoms....
Anthropology of Consciousness
September 1, 2022
Jorgelina Reinoso Niche
AbstractFor the Mexican Otomi of the Sierra Norte de Puebla, Santa Rosa is a sacred plant used by the shaman to heal people and sing in rituals called costumbres. It is also an Antigua, a sacred deity who maintains a constant dialogue with ritual specialists. In the Otomi discourse and its worldview of Santa Rosa, as well as in its ritual process, it is eaten, not smoked. Although it is...
Nature Communications
August 18, 2022
Arvind Kumar, Kayla Kindig, Shanlin Rao et al.
Nociception and motor coordination are critically governed by glycine receptor (GlyR) function at inhibitory synapses. Consequentially, GlyRs are attractive targets in the management of chronic pain and in the treatment of several neurological disorders. High-resolution mechanistic details of GlyR function and its modulation are just emerging. While it has been known that cannabinoids such as...
Current Addiction Reports
August 15, 2022
Bradford Martins, Will Rutland, Joao P De Aquino et al.
Purpose of review: This review summarizes recent clinical trial research on pharmacological treatments for substance use disorders, with a specific focus on agents with potential abuse liability. Recent findings: Pharmacological treatments for substance use disorders may include gabapentinoids, baclofen, modafinil, ketamine, cannabinoids, gamma-hydroxybutyrate, and psychedelics. Gabapentinoids...
IntechOpen eBooks
August 3, 2022
Peter B. Chase
Cannabinoids (phytocannabinoids and synthetic cannabinoids) are most often used during adolescence and given the changing norms, enhanced potency, reduced societal perceptions of risk and multitude forms of products for consumption, clinicians need to be become more cognizant of cannabinoid products and their effects. The aim of this narrative review is to briefly discuss acute toxicities and a...
The Annual Review of Pharmacology and Toxicology
August 1, 2022
R. Roque-Bravo, Rafaela Sofia Silva, R. Malheiro et al.
Synthetic cannabinoids (SCs) are a chemically diverse group of new psychoactive substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions (e.g., elevated mood sensation, relaxation, appetite stimulation) that resemble, but are more intense than, those induced by cannabis. Although some of these effects have been explored for therapeutic applications, anticipated...
African journal of rhetoric
July 26, 2022
Lina Camila Molina-Chala, Ángela Victoria Vera Márquez, Andrés M. Pérez-Acosta et al.
1 citation
The objective of this research was to characterize the discussion forum of a virtual community in which the members addressed drug-related issues for ludic and recreational purposes. Through a netnography approach, a virtual community in Spanish was studied in which users shared content regarding the use of psychoactive substances, mainly cannabis. Data collection was carried out based on 12...