Cannabis for anxiety: all studies (page 2)

Cannabis Use is Related to Anhedonia in Adolescents With Diverse Mood and Anxiety Symptoms.

JAACAP open December 1, 2025 Tram N B Nguyen, Benjamin A Ely, Aria Vitale et al.

Youth with depression use cannabis at high rates, and exposure to cannabinoids in adolescence has been shown to deleteriously alter the reward system. However, there has been sparse research on the link between adolescent cannabis use and anhedonia, a core symptom of depression and clinical manifestation of reward dysfunction. Here, in a sample of adolescents presenting predominantly with mood...

DOI: 10.1016/j.jaacop.2025.02.003 Full text Anxiety Cannabis Depression Anhedonia +1

Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network.

Psychopharmacology November 1, 2025 Marta De Felice, Hanna J Szkudlarek, Matthew J Jones et al.

RATIONALE: Chronic cannabis during adolescence is associated with long-lasting pathological outcomes, and these effects can be remarkably different between the sexes. Preclinical studies in rodents demonstrated that sustained exposure to Δ9-tetrahydrocannabinol (THC), induces sex-specific pathophysiological outcomes. Thus, while males exhibit higher vulnerability to schizophrenia-like...

DOI: 10.1007/s00213-025-06817-8 Full text Anxiety THC Adolescence Females +5

Effects of Cannabinoids on Emotional States and Alcohol Use Among Underrepresented Groups: Moderation by Perceived Discrimination.

Human Psychopharmacology: Clinical and Experimental September 1, 2025 Renée Martin-Willett, Carillon J. Skrzynski, Angela D Bryan et al.

This study examined the effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) on negative mood and drinking behaviors, and whether those effects were moderated by levels of perceived discrimination among participants who identify with a racial, ethnic, gender, or sexual identity that is underrepresented in research. Participants were either not using cannabis, using cannabis with THC, or...

DOI: 10.1002/hup.70016 Full text Anxiety Cannabidiol Tetrahydrocannabinol Alcohol +1

Inflammatory state moderates response to cannabis on negative affect and sleep quality in individuals with anxiety

Frontiers in Behavioral Neuroscience July 1, 2025 Richard G. Hunter, Annelise Madison, Jonathon K. Lisano et al.

Introduction Inflammation has been implicated as an underlying pathology in negative affect and sleep disruption. Cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have demonstrated anti-inflammatory properties. This study aimed to assess if cannabis use altered cytokine concentration and whether inflammatory status moderated the influence of 4 weeks of cannabis use on...

DOI: 10.3389/fnbeh.2025.1549311

Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment.

Biological Psychiatry Global Open Science July 1, 2025 Yalin Sun, Meenalochani Sivasubramanian, Marija Milenkovic et al.

Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. However, the mechanisms that mediate Δ9-tetrahydrocannabinol (THC)-triggered neuroadaptive changes in the maturing amygdala remain unclear. Proteomic analysis of amygdala tissue from male adolescent Saimiri boliviensis nonhuman primates chronically treated with THC provided leads...

DOI: 10.1016/j.bpsgos.2025.100496 Full text Anxiety Adolescent neurodevelopment Amygdala Astrocytes +3

Naturalistic use of psychedelics is associated with longitudinal improvements in anxiety and depression during global crisis times.

Journal of Psychopharmacology June 18, 2025 Maria Bălăeţ, William Trender, Annalaura Lerede et al. 2 citations

Mental health implications of COVID-19 drug use patterns are still unclear. We used data-driven clustering in a large citizen science cohort recruited agnostically to an interest in drug-use to categorise people according to common patterns of drug use and analysed their mental health symptoms (GAD-7 and PHQ-9 items), from recruitment prior to COVID-19 restrictions in 2020 (N = 242,260) to...

DOI: 10.1177/02698811251346729 Full text Well-being Reduced anxiety Reduced depression Improved mental health +5

Long-Term Mental Health and Wellbeing Outcomes Associated with Naturalistic Ayahuasca Consumption.

Journal of Psychoactive Drugs February 20, 2025 Broc A. Pagni, Andreas Halman, Jerome Sarris et al. 7 citations

The durability of ayahuasca's effects on mental health and the influence of clinical diagnoses on therapeutic response is unclear. Adults with no prior exposure to ayahuasca (n = 66) participating in neo-shamanic ayahuasca ceremonies completed questionnaires at baseline, 7 days, and 1, 6, and 12 months. Mixed models were used to characterize temporal trajectories in mental health, alcohol and...

DOI: 10.1080/02791072.2025.2465800 Full text DMT Anxiety Depression Addiction +10

Investigating the Relationship Between Cannabis Expectancies and Anxiety, Depression, and Pain Responses After Acute Flower and Edible Cannabis Use.

Cannabis and Cannabinoid Research February 1, 2025 Margy Y. Chen, Emily B Kramer, Laurel P Gibson et al.

Objective: Cannabis has been touted for a host of pharmacological and therapeutic effects and users commonly report reduced symptoms of physical and mental health conditions, including anxiety, depression, and chronic pain. While there is existing empirical evidence supporting these effects of cannabis use, little is known about the extent to which these effects result from pharmacological...

DOI: 10.1089/can.2023.0264 Full text Anxiety Cannabis Depression Expectancy +2

Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety.

Reviews in the Neurosciences February 26, 2024 Bárbara Dos Anjos Rosário, Jéssica Alves Lemes, Maria Paula De Lima et al.

Social anxiety disorder (SAD) is a debilitating disorder, characterized by fear and anxiety in social situations. Evidence suggests that the levels of SAD are rising, in particularly after the COVID-19 pandemic. Serotonin and noradrenaline reuptake inhibitors and cognitive-behavioral therapy are effective treatments for SAD. Nevertheless, a significant number of patients do not respond well to...

DOI: 10.1515/revneuro-2023-0078 Full text Cannabis Cannabinoids Social anxiety disorder

Cannabis and Anxiety: A Critical Review

Medical Cannabis and Cannabinoids February 23, 2024 Alexander Beletsky, Cherry Liu, Bryson Lochte et al.

Abstract Introduction: Cannabis has been reported to have both anxiogenic and anxiolytic effects. Habitual cannabis use has been associated with anxiety disorders (AD). The causal pathways and mechanisms underlying the association between cannabis use (CU)/cannabis use disorder (CUD) and anxiety remain unclear. We examined the literature via a systematic review to investigate the link between...

DOI: 10.1159/000534855 Full text