Background Ketamine exerts potent but transient antidepressant effects in treatment-resistant depression (TRD). Combinations of ketamine and psychotherapy have attracted interest, but no trial has investigated a psychedelic model of ketamine–psychotherapy for TRD to our knowledge. Aims This secondary analysis of a randomised clinical trial (RCT) explores the therapeutic effects and experiential...
Addressing the escalating environmental crisis requires not only technological and economic solutions but also a transformation in human behavior and organizational practices. This paper examines the potential of mindfulness to foster pro-environmental behaviors (PEBs) by enhancing psychological traits, such as ecological awareness and emotional regulation, that support sustainable actions. It...
Vaporized N,N-Dimethyltryptamine (DMT) has a short duration and simple application, prompting this technique as a new approach for psychedelics' clinical use. Building on our initial dose-ascending studies and addressing potential confounding effects of dosing order, this study is the first to evaluate inhaled DMT in a randomized, placebo-controlled, double-blind design. Given DMT's therapeutic...
Background: Ketamine use for chronic pain and depression has increased worldwide, but sex differences in its efficacy and safety have been little studied; this study examines existing evidence to address this gap. Methods: A prospective, multicenter, one-year observational study in 585 chronic pain patients was performed; 256 patients had one administration of ketamine and 329 had two or more....
Several studies have linked myelin abnormalities with neuropsychiatric disorders; others have implicated psychedelics as a potential therapeutic for such conditions. One risk factor for these demyelinating disorders is a mutation in the Apolipoprotein E gene known as APOE4. This variant impedes the cholesterol regulation of oligodendrocytes responsible for the myelination, or insulation, of...
Dissociative experiences are prevalent in young people, where they are associated with greater clinical severity of co-occurring difficulties and increased risk of self-harm and suicide. Recent research suggests transdiagnostic dissociation plays a role in the development and maintenance of mental health problems such as anxiety, depression and psychosis, and may therefore constitute a novel...
Abstract Background Patients with cancer often struggle with depression, which can negatively impact quality of life as well as be challenging to manage. Methods A phase 2 trial was conducted that demonstrated safety, feasibility, and efficacy of a single dose of psilocybin combined with psychological support in a community cancer setting in 30 patients with cancer and a major depressive...
bioRxivJune 14, 2025Michael Gruenwald, Sebastien De Landtsheer, Thomas Huebl et al.
preprint
Psychological trauma is associated with significant alterations of biological functions and is correlated with epigenetic changes specifically of DNA methylation. Trauma therapy is aiming at relieving the impact of trauma and is in initial studies also correlated with changes in DNA methylation. In this study we explored the changes in whole blood DNA methylation of participants of a program...
Abstract Depression and anxiety are disabling and high incidence mental disorders characterized by phenotypic heterogeneity. Currently available treatments show severe limitations. Thus, there is an urgent need for effective treatments in this population. In the search for novel rapid-acting antidepressants, the psychedelic psilocybin has emerged as a promising therapy in several clinical...
Sexual and gender minority (SGM) individuals experience disproportionately high rates of depression, anxiety, trauma, and discrimination, yet remain underrepresented in psychedelic research. This prospective, naturalistic study explored the impact of an ayahuasca retreat experience on mental health, quality of life, and spiritual well-being among SGM participants. Nineteen individuals attending...