Frontiers in Psychiatry
September 5, 2025
Nicholas J. Ahari, Gregory A. Fonzo
3,4-methelenedioxymethamphetamine (MDMA) can be effective in treating posttraumatic stress disorder (PTSD) in controlled trials, potentially secondary to MDMA’s effects on neural circuits implicated in fear and reward. Although anxiety, stress, and fear-based disorders involve maladaptation of the neural circuits processing fear, threat, and reward, no studies have tested MDMA’s therapeutic...
Pharmaceutical Science
September 4, 2025
Faheema Aziz Wani, Irfan Ahmad Wani
Psychedelic drugs, known for their profound effects on perception, cognition, and emotion, have long captivated scientific, cultural, and therapeutic interest. Following the discovery of LSD’s psychoactive properties in 1943, research surged into its therapeutic potential and the nature of consciousness. However, the integration of psychedelics into the 1960s counterculture led to moral panic,...
Journal of Psychedelic Studies
September 4, 2025
Alan K. Davis, Meghan DellaCrosse, Nathan D. Sepeda et al.
4 citations
Abstract Background Major Depressive Disorder (MDD) is a leading cause of disability and economic loss, with high recurrence and treatment resistance. Psilocybin-assisted therapy (PAT) shows promise in reducing depressive symptoms, but long-term effects are unknown. We aimed to determine the long-term safety and efficacy of PAT for MDD over a five-year follow-up period. Methods Individuals who...
Aries
September 3, 2025
Elly Moseson
Abstract This article concerns a Hasidic homily describing a technique for lucid dream cultivation. The homily outlines a worldview in which fantasy and reality merge, and thoughts, both positive and negative, have real cosmic and personal consequences. To counter the allure of sexual fantasy, the homily recommends a form of Neoplatonic contemplation widely taught within early Hasidic circles....
Journal of Holistic Nursing
September 3, 2025
Ana Cláudia Mesquita Garcia, Felipe Teixeira, Lucas Oliveira Maia
Psychedelic-assisted therapy (PAT) has shown promising results in alleviating psychological and existential suffering among individuals with serious illnesses. In parallel, nursing offers a robust theoretical framework to guide therapeutic communication in this context. This article explores the application of Peplau's Theory of Interpersonal Relations (PTIR) as a foundation for holistic...
The Lancet Child & Adolescent Health
September 2, 2025
Khaleel Rajwani, Edward Jacobs, Lori Bruce et al.
6 citations
The potential use of psychedelic-assisted therapy for adolescents with mental illness has sparked both interest and concern. Modern psychedelic research has focused on adults, and adolescents younger than 18 years are typically excluded due to ethical and legal challenges. To explore whether adolescents have been included in 21st century psychedelic research, we conducted a scoping review of...
Journal of Affective Disorders
September 1, 2025
Xianghong Liu, Lifeng Li, Haijun Li et al.
INTRODUCTION Dysfunction in amygdala networks has been implicated in major depressive disorder (MDD). Pharmacological treatments, such as esketamine and sertraline, are believed to exert their antidepressant effects by modulating amygdalar activity. This study aimed to investigate the relationship between changes in dynamic functional connectivity (dFC) within amygdala subregions and treatment...
Psycho-Oncology
September 1, 2025
Nasim Badaghi, Linda Kwakkenbos, Judith Prins et al.
Online mindfulness-based cognitive therapy (eMBCT) can reduce psychological distress in people with cancer, but adherence and scalability could be improved. Through co-creation, we developed two eMBCT formats: group-blended and individual-unguided. This trial compared the effects of the two eMBCT to care as usual (CAU) on psychological distress and other mental health outcomes in people with...
BMC Complementary Medicine and Therapies
September 1, 2025
Emma Schmelefske, Megan Per, Leena Anand et al.
Non-suicidal self-injury (NSSI) is associated with suicide risk, as well as a number of psychological disorders. This, coupled with its high prevalence rate, make it imperative that effective treatments for those who engage in NSSI are investigated and made available to the public. Despite this, few interventions specifically targeting NSSI have been researched. This study aimed to address this...
Acta Pharmaceutica Sinica B
September 1, 2025
Michał K Jastrzębski, Piotr Wójcik, Angelika Grudzińska et al.
G protein-coupled receptors (GPCRs) represent key drug targets, with approximately 30%-40% of all medications acting on these receptors. Recent advancements have uncovered the complexity of GPCR signaling, including biased signaling, which allows selective activation of specific intracellular pathways-primarily mediated by G proteins and β-arrestins. Among aminergic GPCRs, the serotonin 5-HT2A...