ABSTRACT The psychedelic psilocybin has gained popularity in recent years as a therapy for treatment‐resistant depression and has been reported to reduce symptoms of depression and anxiety. Psilocybin's active metabolite, psilocin, possesses a binding affinity for serotonin receptors as well as for the serotonin transporter (5‐HTT). We recently reported that in contrast to wild‐type mice,...
A fundamental challenge in clinical neuropsychology is the objective assessment of emotion regulation and resilience. Current reliance on self-report is hampered by bias, creating a critical need for brain-based biomarkers that can capture the dynamics of emotional functioning. This review advances EEG entropy modulation as a theoretically appealing and emerging candidate. Converging research...
Perinatal opioid use disorder (OUD) remains a public health epidemic. Stress, anxiety and depression are disproportionately high among this population and are associated with poor recovery outcomes. Mindfulness interventions show promise for supporting recovery for women. This paper reports results of a pilot study to evaluate initial efficacy and acceptability of digitally delivered...
The global population is ageing rapidly, with the number of individuals aged 60 and older reaching 1 billion in 2019 and expected to double by 2050. As people age, neuropsychological health often deteriorates, leading to a higher prevalence of age-related depression. Symptoms may include anxiety, apathy, mood instability, sadness, and, in severe cases, suicidal thoughts. Depression in the...
Migraine is the second leading cause of disability worldwide, contributing to high healthcare costs, reduced work productivity, and diminished quality of life. Non-pharmacological therapies such as repetitive transcranial magnetic stimulation (rTMS) and mindfulness-based practices (MBPs) have independently demonstrated effectiveness in reducing headache frequency and medication use, offering...
The relevance of the research topic. The article is devoted to an overview of mindfulness technology and its application in psychological practice and cognitive- behavioral therapy. The essence of mindfulness practice is described and a historical sketch of its emergence and development is made. Research methodology. Theoretical models of mindfulness are considered, including the decentering...
Body scan meditation is a popular mindfulness practice in which a person directs their attention toward internal bodily sensations. Although its neural mechanisms have been investigated using functional magnetic resonance imaging, few studies have used functional near-infrared spectroscopy (fNIRS) to directly measure prefrontal networks during body scan meditation. In this study, symptoms of...
Post-detoxification phases of methamphetamine dependence are often characterized by neurophysiological instability, including tremors, insomnia, and anxiety, due to suppressed GABAergic activity and hyperdopaminergic rebound. Traditional Filipino distilled spirit, álak or lambanog, contains trace levels of ethanol and minor fusel alcohols which may exert mild GABA-A receptor agonism when...
BACKGROUND: Major depressive disorder (MDD) is a leading cause of global disability, and current treatments often fail to provide sustained effectiveness. MDMA-assisted therapy (MDMA-AT) is a promising treatment for MDD. However, the long-term effects are not known. OBJECTIVES: To examine the long-term effects of MDMA-AT for MDD. METHODS: Twelve participants with MDD and an ongoing moderate to...
Autism in AdulthoodNovember 26, 2025T. Hirvikoski, Hanna Agius, Gustaf Wettermark et al.
Autistic adults often experience high levels of stress and difficulties in coping with stressors in everyday life. The aim of this study was to evaluate the effectiveness of mindfulness-based stress reduction (MBSR) groups, adjusted for autistic adults in an outpatient context. We conducted a two-arm, parallel-group, randomized controlled effectiveness trial during the years 2018–2020. Autistic...