Abstract Background Mindfulness-based approaches have gained increasing attention in mental health research and clinical practice. However, most empirical evidence on mindfulness has been generated in Western populations, with comparatively limited synthesis of research conducted in non-WEIRD contexts. Aims This scoping review aims to map and synthesize existing research on mindfulness...
Introduction. Limitations of conventional treatments for depression and anxiety, particularly in treatment-resistant cases, have driven interest in alternative therapeutic approaches. Psilocybin, a serotonergic agonist with demonstrated effects on neuroplasticity and large-scale brain networks, has emerged as a promising therapeutic option. Materials and methods: A systematic review of...
HealthcareApril 21, 2026Chiara Bianchi, Laura Rotondo, Claudio Bersani et al.
Background: Psychological distress, autonomic dysregulation, and unhealthy lifestyle behaviors are common after myocardial infarction (MI) and negatively affect cardiovascular outcomes. In recent years, integrative mind-body interventions, such as yoga and mindfulness-based approaches, have gained increasing attention as adjuncts to conventional cardiac rehabilitation (CR) programs. However,...
Objectives: To test the effectiveness of mindful compassion integrated with body-mind-spirit (BMS) therapy delivered through a blended face-to-face and online approach for breast cancer patients. Methods: This randomized controlled trial (RCT) assigned 39 breast cancer patients to either a blended group (partial face-to-face and online sessions) or an online-only group. Both received eight...
Scientific ReportsApril 21, 2026Rong Ding, Daojie Wang, Guoxin Wang et al.
Elderly colorectal cancer (CRC) patients face high risks of postoperative depression state, inadequately addressed by opioid-based analgesia. Esketamine, an NMDA receptor antagonist with rapid antidepressant effects, offers potential benefits but lacks evidence in this population. This double-blind RCT enrolled 99 elderly (≥ 65 years) CRC resection patients, randomized to three postoperative...
Mindfulness-Based Interventions (MBIs) are widely used in primary care for pain and mental health, but gender-specific outcomes are under-researched. A systematic review was conducted using PRISMA 2020 guidelines. Studies from Scopus, Web of Science, and PubMed (1987-2023) with gender-disaggregated data were included. Elicit AI assisted in screening, data extraction, and thematic clustering....
Mushroom use dates back to ancient times, and it currently remains significant among indigenous and urban populations as a medicinal option. Psilocybe species are suggested to modify emotions when administered in macro- or microdose form for the treatment of anxiety and depression, both often affected by a delayed onset and adverse effects of current pharmacological therapy. The objective of...
April 17, 2026Sara Arciniegas Ruiz, Sari Prutchi Sagiv, Hagit Eldar-Finkelman
Fibromyalgia (FM) is a chronic pain condition characterized by widespread pain, fatigue, sleep disturbances, and mood changes. Available treatments often provide limited relief, highlighting the need for new therapeutic approaches. Repurposing offers a faster and more cost-effective path to innovation. Lysergic acid diethylamide (LSD), historically known for its psychedelic effects, has...
Esta revisión analiza cómo la suplementación con L-triptófano en el sustrato de cultivo de Psilocybe cubensis potencia la biosíntesis de psilocibina vía las enzimas PsiD, PsiH, PsiK y PsiM, alcanzando aumentos significativos en laconcentración alcaloide respecto a controles sin suplemento.La psilocibina después de ser ingerida se convierte en psilocina por un proceso de desfosforilación, que...
The study examined how the different psychological constructs of mindfulness, anxiety, and positive fantasy engagement influence tourist fatigue in digitally mediated tourism experiences. In response to the increasing anxiety regarding cognitive overload in AI-driven travel ecosystems, the study reconceptualizes fatigue as configuration-dependent, but not uniformly experienced. Composite...