Cancer ResearchJanuary 16, 2024Kelsey Klute, Lou Lukas, Soonjo Hwang et al.2 citations
Abstract Background: Psychological distress is a common reaction to a cancer diagnosis and its treatment. Distress impacts quality of life, adherence to treatment, decision making and survival. Patients with pancreatic adenocarcinoma (PDAC) experience exceptionally high rates of psychological distress, most commonly depression, anxiety and suicidality. Psilocybin, a serotonergic psychedelic...
Psicologia e Saúde em DebateJanuary 10, 2024Leonardo Hercílio Florêncio Silva, Júnia Aparecida Laia Da Mata, Sabrina Stefanello et al.
Psilocybin is a natural substance with hallucinogenic properties that has recently been used in the field of health. It is an alkaloid that, when associated with psychotherapy, has shown benefits in the treatment of depression and anxiety. This study aims to analyze the current state of knowledge about the psychological effects of psilocybin in patients with terminal cancer. The method used was...
Introduction There is a resurgence of interest in the therapeutic potential of psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA). Primary findings from our randomized, double-blind, placebo-controlled, multi-site Phase 3 clinical trial of participants with severe PTSD (NCT03537014) showed that MDMA-assisted therapy induced significant attenuation in the...
The authors wish to express their regret regarding an error in the publication of the original article. In Table 3, titled “Psilocybin studies on depressive disorders,” specifically in the fourth row related to the study conducted by Carhart-Harris et al. (2016), the main results column inaccurately presented the Cohen's d figure, which included data from Carhart-Harris et al. (2018) that...
Abstract Introduction N,N-Dimethyltryptamine (DMT), a naturally occurring psychedelic tryptamine contained in the indigenous ayahuasca brew has shown antidepressant effects. This Phase 2a clinical trial investigates for the first time the efficacy of isolated DMT in treatment-resistant depression (TRD). Methods Six TRD patients participated in an open-label, fixed-order, dose-escalation study,...
Objective:Ketamine has proved effective as a rapid-acting antidepressant agent, but treatment is not effective for everyone (approximately a quarter to a half of patients). Some adult studies have begun to investigate predictors of ketamine's antidepressant response, but no studies have examined this in adolescents with depression. Methods:We conducted a secondary data analysis of adolescents...
AbstractBackgroundPersistent mind‐wandering processes are associated with negative emotions; however, mindful states exhibit an anticorrelation with mind‐wandering patterns. The aim of this study is to investigate the mediating role of excessive mind wandering (EMW), rumination, and trait mindfulness between attention‐deficit hyperactivity disorder (ADHD) symptoms and the severity of...
Purpose: The aim of the present study was to compare the effectiveness of Hatha Yoga exercises and mindfulness-based therapy on generalized anxiety and existential anxiety in physically active and inactive men aged 30 to 50 years in the city of Kermanshah. Methods and Materials: This study employed a quasi-experimental design with a pre-test, post-test, and a 2-month follow-up period, along...
The present study aimed to examine the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on anxiety and rumination levels in women diagnosed with Body Dysmorphic Disorder (BDD). This study employed a quasi-experimental design with pre-test and post-test measures to assess changes in both the experimental and control groups. The statistical population consisted of all women diagnosed...
Objective: Pregnancy is a unique period in the life of every woman. Although pregnancy and childbirth can be a pleasant and enjoyable experience, they are also considered stressful experiences. Therefore, this study aimed to compare the effectiveness of Mindfulness-Based Stress Reduction (MBSR) and Acceptance and Commitment Therapy (ACT) on psychological well-being and death anxiety in pregnant...
Objective: The primary objective of this study was to evaluate the effectiveness of the Mindfulness-Based Stress Reduction (MBSR) program on reducing anxiety, rumination, and dysfunctional attitudes in men undergoing drug-free addiction treatment. Methods and Materials: This randomized controlled trial included 30 men undergoing drug-free addiction treatment in Ahvaz city. Participants were...
Following acute coronary syndrome (ACS), up to 40% of patients report elevated depressive symptoms which is associated with a two-fold increase in mortality risk due to behavioral and biological mechanisms. Mindfulness-Based Cognitive Therapy (MBCT) delivered via synchronous group videoconferencing could help reduce depressive symptoms. To guide MBCT adaptation for ACS patients for a future...
Background: Pregnancy is a particular time when women go through a lot of changes. A challenging period might come up for pregnant moms. A woman's body undergoes ongoing changes to care for the developing foetus. An extensive spectrum of physical and mental symptoms can be associated with pregnancy, and each woman will experience it uniquely. Yoga unites the mind and body by including...
Speech, singing, and vocal communication are fuelled by breath. Anxiety can impact breath and voice negatively, resulting in physiological constrictions that are bi-directionally related to psychological and emotional spheres. There is little theoretical and practical examination of anxiety-specific populations or the mechanistic role of respiration within singing for mental health (SFMH)...
This study investigated the effect of nightmare on sleep disturbance and emotional dysregulation among University Students.The sample size comprised of 300 students which include 150 males and 150 females. Data was taken from the different departments of Government Post Graduate College for boys and University of Haripur by using the purposive sampling technique. Three instruments were used to...
Anxiety disorder is one of the most prevalent mental disorders. Mindfulness-based cognitive therapy (MBCT) is effective for treating anxiety disorders. However, no studies have investigated the cost-effectiveness of MBCT for anxiety disorders. We aimed to conduct a cost-effectiveness analysis alongside a randomized controlled trial (RCT) to clarify the cost-effectiveness of MBCT for anxiety...
The pervasiveness of anxiety and stress among college students necessitates the investigation of potential alternative and accessible interventions which can be implemented into existing curricular and student-support programming to improve students' mental health. Mindfulness based cognitive therapy (MBCT) smartphone applications have shown promising outcomes in alleviating anxiety and stress....
This study reports on 10 frontline healthcare workers, employed during the COVID-19 pandemic and experiencing symptoms of burnout and PTSD, treated with group ketamine-assisted psychotherapy (KAP) in a private outpatient clinic setting. Participants attended 6 sessions once weekly. These included 1 preparation session, 3 ketamine sessions (2 sublingual, 1 intramuscular), 2 integration sessions....
This article provides an overview of the current views on psychedelics and explores their connection to well-being based on scientific research and anecdotal evidence. The article begins by examining the historical context of psychedelics. It then delves into the subsequent prohibition and resurgence of scientific interest in psychedelics, highlighting key studies that have shaped our...
Psychedelics are a class of drugs that can occasion similar changes in conscious ex- periences mediated via the G-protein coupled Serotonin 2A receptor. These changes vary from slight distortions in perceptions to pseudohallucinations and the experienced cessation of a personal self distinct from and necessary for conscious experience, known as ego-dissolution. Psychedelics produce positive...