Altered states of consciousness: all studies (page 34)

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.

Neuropsychopharmacology September 12, 2025 Jakub Vohryzek, Andrea I. Luppi, Selen Atasoy et al. 2 citations

Exploring the intricate relationship between brain's structure and function, and how this affects subjective experience is a fundamental pursuit in neuroscience. Psychedelic substances offer a unique insight into the influences of specific neurotransmitter systems on perception, cognition and consciousness. Specifically, their impact on brain function propagates across the structural connectome...

DOI: 10.1038/s41386-025-02190-4 Full text DMT N-dimethyltryptamine Psychedelic Hallucinogen +19

DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers.

Frontiers in Psychiatry August 15, 2025 Yvonne Bonomo, Amanda F. Norman, Lisa Collins et al. 1 citation

Introduction: Ayahuasca is a psychedelic compound of N, N, Dimethyltryptamine (DMT) and harmala alkaloids used for spiritual and medicinal applications in traditional settings. A range of potential psychotherapeutic mechanisms have been proposed for ayahuasca. These are thought to contribute to improvements in various psychiatric conditions including mood disorders and substance dependence....

DOI: 10.3389/fpsyt.2025.1545915 Full text Psychoactive Compounds DMT Harmala alkaloids Acacia Psychedelics +10

Oceanic states of consciousness-an existential-neuroscience perspective.

Frontiers in Human Neuroscience August 11, 2025 Human-Friedrich Unterrainer 1 citation

Oceanic states of consciousness-characterized by ego dissolution, unity, and timelessness-have long occupied a liminal space between psychopathology and transcendence. This paper explores these states through the interdisciplinary lens of existential neuroscience, integrating insights from psychoanalysis, existentialism, affective neuroscience, and psychedelic research. Starting with the...

DOI: 10.3389/fnhum.2025.1653801 Full text Neurobiology Brain science Mystical experiences Oceanic states +6

The void and the brain.

Cell Reports July 22, 2025 Christof Koch 1 citation

Blackburne et al. track the electroencephalogram activity of volunteers inhaling a high dose of the powerful psychedelic 5-methoxy-N,N-dimethyltryptamine, revealing profoundly slowed-down brain activity but no significant reduction of alpha band power that is typical of other psychedelics.1.

DOI: 10.1016/j.celrep.2025.116072 Full text 5-MEO-DMT Psychedelics Hallucinogens Entheogens +10

Examining mystical experiences as a predictor of psilocybin-assisted psychotherapy for treatment-resistant depression

Journal of Psychopharmacology July 1, 2025 Ryan M Brudner, Erica Kaczmarek, Marc G Blainey et al. 3 citations

Background: Psilocybin-assisted psychotherapy (PAP) is a promising treatment for various psychiatric disorders. However, the exact biological and psychological mechanisms of action of PAP remain to be determined. Examining predictors of PAP outcomes may help identify necessary processes for positive treatment outcomes. Mystical experiences are considered a key aspect of the subjective effects...

DOI: 10.1177/02698811251346697 Major depressive disorder Treatment-resistant depression Psychedelic therapy Psychedelic-assisted therapy +12

The Induction of Dissociative States: A Meta-Analysis.

Biological Psychiatry Global Open Science July 1, 2025 Benjamin Brake, Lillian Wieder, Natasha Hughes et al. 5 citations

Dissociative states, characterized by discontinuities in awareness and perception, occur in a diverse array of psychiatric disorders and contexts. These states have been experimentally modeled in the laboratory through various induction methods, but relatively little is known about the efficacy and comparability of different experimental methods. In this meta-analysis, we quantified...

DOI: 10.1016/j.bpsgos.2025.100521 Full text Ketamine PTSD Non-ordinary states Mirror gazing +19

Safety, tolerability and subjective effects of vaporized N,N-Dimethyltryptamine: A randomized double-blind clinical trial.

European Neuropsychopharmacology June 17, 2025 Isabel Wießner, Marcelo Falchi-Carvalho, Sophie Laborde et al. 7 citations

Vaporized N,N-Dimethyltryptamine (DMT) has a short duration and simple application, prompting this technique as a new approach for psychedelics' clinical use. Building on our initial dose-ascending studies and addressing potential confounding effects of dosing order, this study is the first to evaluate inhaled DMT in a randomized, placebo-controlled, double-blind design. Given DMT's therapeutic...

DOI: 10.1016/j.euroneuro.2025.06.002 Full text Psychedelic therapy N,N-Dimethyltryptamine Placebo-controlled study Psychedelics +17

Inner Light and the Eyes of the Soul: A Phenomenological Analysis of Teresa of Ávila's Visions through the Lens of Phosphene Taxonomy

PsyArXiv Preprints June 16, 2025 preprint

This paper examines the visionary experiences of Saint Teresa of Ávila (1515–1582) as described in The Life of Teresa of Jesus, through the lens of contemporary phenomenology and the six-phase taxonomy of meditation-induced phosphenes. Special attention is given to Chapters 27–38, including her iconic vision of pure inner light and the Transverberation experience. We argue that Teresa’s...

Full text Asc Meditation Contempation Hildegard of bingen, +10

Out of body experiences: Scoping review.

Explore June 4, 2025 Jenny Moix, Samantha Baldaccini, Marta Isern

Despite the growing body of scientific research on Out of Body Experiences (OBEs), a scoping review has not yet been conducted. A search was conducted across six databases. Studies published between 1987 and 2024 were included, resulting in the selection of 87 publications. The analyzed factors included deliberate inducing, predisposing, precipitating, consequential, phenomenological, and...

DOI: 10.1016/j.explore.2025.103196 Full text Lucid dreaming Transcendental experiences Out-of-body experiences obes Astral projection +8

Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self

Imaging Neuroscience April 16, 2025 Lorenzo Pasquini, Alexander J. Simon, Courtney L. Gallen et al. 4 citations

Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory distortions and visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer a valuable approach for identifying...

DOI: 10.1162/imag_a_00541 Default mode network Non-ordinary states Ego dissolution DMT: Dimethyltryptamine +25

Research